Molecular biomarkers for vascular cognitive impairment and dementia

S Hosoki, GK Hansra, T Jayasena, A Poljak… - Nature Reviews …, 2023 - nature.com
As disease-specific interventions for dementia are being developed, the ability to identify the
underlying pathology and dementia subtypes is increasingly important. Vascular cognitive …

Protein S-sulfhydration: unraveling the prospective of hydrogen sulfide in the brain, vasculature and neurological manifestations

R Gupta, M Sahu, R Tripathi, RK Ambasta… - Ageing Research …, 2022 - Elsevier
Hydrogen sulfide (H 2 S) and hydrogen polysulfides (H 2 S n) are essential regulatory
signaling molecules generated by the entire body, including the central nervous system …

URB597 and Andrographolide Improve Brain Microvascular Endothelial Cell Permeability and Apoptosis by Reducing Oxidative Stress and Inflammation Associated …

DP Wang, K Kang, J Sun, Q Lin… - Oxidative Medicine and …, 2022 - Wiley Online Library
Ischemic stroke, a cerebrovascular disease worldwide, triggers a cascade of
pathophysiological events, including blood‐brain barrier (BBB) breakdown. Brain …

Emerging role of white matter lesions in cerebrovascular disease

A Rastogi, R Weissert… - European Journal of …, 2021 - Wiley Online Library
White matter lesions have been implicated in the setting of stroke, dementia, intracerebral
haemorrhage, several other cerebrovascular conditions, migraine, various …

[HTML][HTML] The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment

A Ungvari, R Gulej, B Csik, P Mukli, S Negri, S Tarantini… - Nutrients, 2023 - mdpi.com
As aging societies in the western world face a growing prevalence of vascular cognitive
impairment and Alzheimer's disease (AD), understanding their underlying causes and …

[HTML][HTML] Cerebral small vessel disease mediates the association between homocysteine and cognitive function

Z Teng, J Feng, R Liu, Y Ji, J Xu, X Jiang… - Frontiers in aging …, 2022 - frontiersin.org
Objective To investigate the relations of serum total homocysteine (tHcy) with cerebral small
vessel disease (CSVD) and cognitive function and evaluate whether CSVD mediates the …

[HTML][HTML] Small vessel disease: Ancient description, novel biomarkers

R Moretti, P Caruso - International Journal of Molecular Sciences, 2022 - mdpi.com
Small vessel disease (SVD) is one of the most frequent pathological conditions which lead
to dementia. Biochemical and neuroimaging might help correctly identify the clinical …

[HTML][HTML] Pathogenesis and research progress in leukoaraiosis

L Sun, L Hui, Y Li, X Chen, R Liu, J Ma - Frontiers in Human …, 2022 - frontiersin.org
Leukoaraiosis is a common imaging marker of cerebral small vessel disease. In recent
years, with the continuous advances in brain imaging technology, the detection rate of …

Association of serum homocysteine levels with intestinal flora and cognitive function in schizophrenia

H Li, H Li, Z Zhu, X Xiong, Y Huang, Y Feng, Z Li… - Journal of psychiatric …, 2023 - Elsevier
Some studies have indicated that elevated homocysteine (Hcy) levels and intestinal flora
may be involved in schizophrenia (SZ) cognition pathophysiology. This study was the first to …

[HTML][HTML] The Metabolic Impact of Nonalcoholic Fatty Liver Disease on Cognitive Dysfunction: A Comprehensive Clinical and Pathophysiological Review

M Giuffrè, N Merli, M Pugliatti, R Moretti - International Journal of …, 2024 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) exponentially affects the global healthcare burden,
and it is currently gaining increasing interest in relation to its potential impact on central …