The chlorine disinfection by‐products, dichloroacetic acid (DCA) and trichloroacetic acid
(TCA), are carcinogenic in mouse liver. We have previously reported that DCA and TCA …

This study was undertaken to determine whether primary spermatocyte nuclei can complete
meiosis after transfer into maturing or mature oocytes and can participate in normal …

The regulation of eukaryotic gene expression is a complex process. DNA methylation plays
a role in this scheme by acting in cis to modulate protein-DNA interactions. For most …

Purpose: Ionizing radiation induces cellular damage through both direct and indirect
mechanisms, which may include effects from epigenetic changes. The purpose of this study …

To investigate the molecular mechanisms that control expression of smooth muscle cell
(SMC) differentiation genes, we have isolated the human SM22α gene, which is composed …

Alzheimer's disease (AD) was described more than a century ago. However, there are still
no effective approaches to its treatment, which may suggest that the search for the cure is …

A gene encoding a new member of the Pur protein family, Purγ, has been detected upstream
of, and contrapodal to, the gene encoding the Werner syndrome helicase, Wrn, at human …

Methylation of CpG islands is an established transcriptional repressive mechanism and is a
feature of silencing in X chromosome inactivation. Housekeeping genes that are subject to X …

Maternal nutrition during gestation is a leading factor of modifying the foetal epigenome and
phenotype for mammals. Imprinting genes have important roles in regulating foetal growth …

In the present study, the isolation and characterization of two distinct cDNAs that code for
carrot DNA (cytosine‐5)‐methyltransferase (DNA‐METase) are reported. The screening of a …