A paclitaxel and microRNA-124 coloaded stepped cleavable nanosystem against triple negative breast cancer

C Chen, M Shen, H Liao, Q Guo, H Fu, J Yu… - Journal of …, 2021 - Springer
Background Triple negative breast cancer (TNBC) is one of the most biologically aggressive
breast cancers and lacks effective treatment options, resulting in a poor prognosis …

Anticancer effect of benzimidazole derivatives, especially mebendazole, on triple-negative breast cancer (TNBC) and radiotherapy-resistant TNBC in vivo and in vitro

HS Choi, YS Ko, H Jin, KM Kang, IB Ha, H Jeong… - Molecules, 2021 - mdpi.com
In this study, we aimed to evaluate the anticancer effect of benzimidazole derivatives on
triple-negative breast cancer (TNBC) and investigate its underlying mechanism of action …

Discovery of novel polycyclic heterocyclic derivatives from evodiamine for the potential treatment of triple-negative breast cancer

S Xu, H Yao, Y Qiu, M Zhou, D Li, L Wu… - Journal of Medicinal …, 2021 - ACS Publications
Evodiamine (Evo) is a quinazolinocarboline alkaloid found in Evodia rutaecarpa and
exhibits moderate antiproliferative activity. Herein, we report using a scaffold-hopping …

Identification of potential key genes and pathways predicting pathogenesis and prognosis for triple-negative breast cancer

X Lv, M He, Y Zhao, L Zhang, W Zhu, L Jiang… - Cancer cell …, 2019 - Springer
Background Triple negative breast cancer (TNBC) is a specific subtype of breast cancer with
a poor prognosis due to its aggressive biological behaviour and lack of therapeutic targets …

Sophoraflavanone G suppresses the progression of triple‐negative breast cancer via the inactivation of EGFR–PI3K–AKT signaling

W Cheng, D Liu, M Guo, H Li… - Drug development …, 2022 - Wiley Online Library
Sophoraflavanone G (SG), a prenylated flavonoid extracted from Sophora flavescens, has
been found to possess antitumor activity in several types of human cancer. However, the …

Exosomes in triple negative breast cancer: From bench to bedside

W Tang, M Xia, Y Liao, Y Fang, G Wen, J Zhong - Cancer Letters, 2022 - Elsevier
Exosomes are lipid bilayer extracellular vesicles with a size of 30–150 nm, which can be
released by various types of cells including breast cancer cells. Exosomes are enriched with …

[HTML][HTML] Caspase-3 mediated switch therapy of self-triggered and long-acting prodrugs for metastatic TNBC

HR Kim, YS Cho, SW Chung, JU Choi, YG Ko… - Journal of Controlled …, 2022 - Elsevier
Triple-negative breast cancer (TNBC) is characterized by its highly heterogeneous
microenvironment and propensity for aggressive behavior, both of which represent, along …

Efficacy and safety of PD-1/PD-L1 inhibitors in triple-negative breast cancer: a systematic review and meta-analysis

M Zhang, J Song, H Yang, F Jin, A Zheng - Acta Oncologica, 2022 - Taylor & Francis
Objective Triple-negative breast cancer (TNBC) is a subtype of breast cancer with a poor
prognosis that seriously threatens women's health. There is still a lack of effective …

CSCs in breast cancer—one size does not fit all: Therapeutic advances in targeting heterogeneous epithelial and mesenchymal CSCs

A Sulaiman, S McGarry, X Han, S Liu, L Wang - Cancers, 2019 - mdpi.com
Unlike other breast cancer subtypes, triple-negative breast cancer (TNBC) has no specific
targets and is characterized as one of the most aggressive subtypes of breast cancer that …

Discovery of novel G9a/GLP covalent inhibitors for the treatment of triple-negative breast cancer

Q Zhang, B Chang, Q Feng, L Li - European Journal of Medicinal Chemistry, 2023 - Elsevier
Triple-negative breast cancer (TNBC) has become a serious threat to women's health.
Research on epigenetic drugs is gradually deepening and is expected to provide new …