Discovery of novel G9a/GLP covalent inhibitors for the treatment of triple-negative breast cancer
Q Zhang, B Chang, Q Feng, L Li - European Journal of Medicinal Chemistry, 2023 - Elsevier
Triple-negative breast cancer (TNBC) has become a serious threat to women's health.
Research on epigenetic drugs is gradually deepening and is expected to provide new …
Research on epigenetic drugs is gradually deepening and is expected to provide new …
CSCs in breast cancer—one size does not fit all: Therapeutic advances in targeting heterogeneous epithelial and mesenchymal CSCs
Unlike other breast cancer subtypes, triple-negative breast cancer (TNBC) has no specific
targets and is characterized as one of the most aggressive subtypes of breast cancer that …
targets and is characterized as one of the most aggressive subtypes of breast cancer that …
Crosstalk between immune checkpoint modulators, metabolic reprogramming and cellular plasticity in triple-negative breast cancer
A Poddar, SR Rao, P Prithviraj, G Kannourakis… - Current …, 2022 - mdpi.com
Breast cancer is one of the major causes of mortality in women worldwide. Accounting for 15–
20% of all breast cancer diagnoses, the triple-negative breast cancer (TNBC) subtype …
20% of all breast cancer diagnoses, the triple-negative breast cancer (TNBC) subtype …
JAC1 targets YY1 mediated JWA/p38 MAPK signaling to inhibit proliferation and induce apoptosis in TNBC
Z Zhai, Y Ren, C Shu, D Chen, X Liu, Y Liang, A Li… - Cell Death …, 2022 - nature.com
Triple negative breast cancer (TNBC) is a type of breast cancer with poor prognosis, and has
no ideal therapeutic target and ideal medicine. Downregulation of JWA is closely related to …
no ideal therapeutic target and ideal medicine. Downregulation of JWA is closely related to …
[HTML][HTML] Role of platelets and breast cancer stem cells in metastasis
G Mendoza-Almanza… - World journal of stem …, 2020 - ncbi.nlm.nih.gov
The high mortality rate of breast cancer is mainly caused by the metastatic ability of cancer
cells, resistance to chemotherapy and radiotherapy, and tumor regression capacity. In recent …
cells, resistance to chemotherapy and radiotherapy, and tumor regression capacity. In recent …
Exploring the resistance mechanism of triple-negative breast cancer to paclitaxel through the scRNA-seq analysis
W Gao, L Sun, J Gai, Y Cao, S Zhang - Plos one, 2024 - journals.plos.org
Background The triple negative breast cancer (TNBC) is the most malignant subtype of
breast cancer with high aggressiveness. Although paclitaxel-based chemotherapy scenario …
breast cancer with high aggressiveness. Although paclitaxel-based chemotherapy scenario …
Characteristics and prognostic significance of polo‐like kinase‐1 (PLK1) expression in breast cancer
Aim Polo‐like kinase‐1 (PLK1) plays a crucial role in cell cycle progression, and it is
considered a potential therapeutic target in many cancers. Although the role of PLK1 is well …
considered a potential therapeutic target in many cancers. Although the role of PLK1 is well …
Discovery of a novel small-molecule inhibitor of Fam20C that induces apoptosis and inhibits migration in triple negative breast cancer
R Zhao, L Fu, Z Yuan, Y Liu, K Zhang, Y Chen… - European Journal of …, 2021 - Elsevier
The family with sequence similarity 20, member C (Fam20C), a Golgi casein kinase, has
been recently regarded as a potential therapeutic target for the treatment of triple negative …
been recently regarded as a potential therapeutic target for the treatment of triple negative …
Multifunctional albumin-stabilized gold nanoclusters for the reduction of cancer stem cells
Controlled delivery of multiple chemotherapeutics can improve the effectiveness of
treatments and reduce side effects and relapses. Here in, we used albumin-stabilized gold …
treatments and reduce side effects and relapses. Here in, we used albumin-stabilized gold …
Immunoadjuvant nanoparticles as trojan horses for enhanced photo-immunotherapy in the treatment of triple-negative breast cancer
J Wu, S Wang, S Liu, F Liu, F Zhou - Frontiers in pharmacology, 2022 - frontiersin.org
Treatment of triple-negative breast cancer (TNBC) faces great challenges due to high
invasiveness and poor prognosis. Therefore, effective treatment methods are urgently …
invasiveness and poor prognosis. Therefore, effective treatment methods are urgently …