Discovery of novel G9a/GLP covalent inhibitors for the treatment of triple-negative breast cancer

Q Zhang, B Chang, Q Feng, L Li - European Journal of Medicinal Chemistry, 2023 - Elsevier
Triple-negative breast cancer (TNBC) has become a serious threat to women's health.
Research on epigenetic drugs is gradually deepening and is expected to provide new …

CSCs in breast cancer—one size does not fit all: Therapeutic advances in targeting heterogeneous epithelial and mesenchymal CSCs

A Sulaiman, S McGarry, X Han, S Liu, L Wang - Cancers, 2019 - mdpi.com
Unlike other breast cancer subtypes, triple-negative breast cancer (TNBC) has no specific
targets and is characterized as one of the most aggressive subtypes of breast cancer that …

Crosstalk between immune checkpoint modulators, metabolic reprogramming and cellular plasticity in triple-negative breast cancer

A Poddar, SR Rao, P Prithviraj, G Kannourakis… - Current …, 2022 - mdpi.com
Breast cancer is one of the major causes of mortality in women worldwide. Accounting for 15–
20% of all breast cancer diagnoses, the triple-negative breast cancer (TNBC) subtype …

JAC1 targets YY1 mediated JWA/p38 MAPK signaling to inhibit proliferation and induce apoptosis in TNBC

Z Zhai, Y Ren, C Shu, D Chen, X Liu, Y Liang, A Li… - Cell Death …, 2022 - nature.com
Triple negative breast cancer (TNBC) is a type of breast cancer with poor prognosis, and has
no ideal therapeutic target and ideal medicine. Downregulation of JWA is closely related to …

[HTML][HTML] Role of platelets and breast cancer stem cells in metastasis

G Mendoza-Almanza… - World journal of stem …, 2020 - ncbi.nlm.nih.gov
The high mortality rate of breast cancer is mainly caused by the metastatic ability of cancer
cells, resistance to chemotherapy and radiotherapy, and tumor regression capacity. In recent …

Exploring the resistance mechanism of triple-negative breast cancer to paclitaxel through the scRNA-seq analysis

W Gao, L Sun, J Gai, Y Cao, S Zhang - Plos one, 2024 - journals.plos.org
Background The triple negative breast cancer (TNBC) is the most malignant subtype of
breast cancer with high aggressiveness. Although paclitaxel-based chemotherapy scenario …

Characteristics and prognostic significance of polo‐like kinase‐1 (PLK1) expression in breast cancer

AG Lashen, MS Toss, L Wootton, AR Green… - …, 2023 - Wiley Online Library
Aim Polo‐like kinase‐1 (PLK1) plays a crucial role in cell cycle progression, and it is
considered a potential therapeutic target in many cancers. Although the role of PLK1 is well …

Discovery of a novel small-molecule inhibitor of Fam20C that induces apoptosis and inhibits migration in triple negative breast cancer

R Zhao, L Fu, Z Yuan, Y Liu, K Zhang, Y Chen… - European Journal of …, 2021 - Elsevier
The family with sequence similarity 20, member C (Fam20C), a Golgi casein kinase, has
been recently regarded as a potential therapeutic target for the treatment of triple negative …

Multifunctional albumin-stabilized gold nanoclusters for the reduction of cancer stem cells

A Latorre, A Latorre, M Castellanos, C Rodriguez Diaz… - Cancers, 2019 - mdpi.com
Controlled delivery of multiple chemotherapeutics can improve the effectiveness of
treatments and reduce side effects and relapses. Here in, we used albumin-stabilized gold …

Immunoadjuvant nanoparticles as trojan horses for enhanced photo-immunotherapy in the treatment of triple-negative breast cancer

J Wu, S Wang, S Liu, F Liu, F Zhou - Frontiers in pharmacology, 2022 - frontiersin.org
Treatment of triple-negative breast cancer (TNBC) faces great challenges due to high
invasiveness and poor prognosis. Therefore, effective treatment methods are urgently …