Epidermal growth factor receptor (EGFR) is the first discovered member of the receptor
tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in …

E3 ligases are a class of enzymes that can transfer ubiquitin to substrates for their
degradation, which are of importance in cellular homeostasis. Since many oncogenic or …

MAVS and MITA are essential adaptor proteins mediating innate antiviral immune
responses against RNA and DNA viruses, respectively. Here we show that RNF115 plays …

Protein–protein interaction cascades are crucial for cellular signaling pathways and cell
morphogenesis. Membrane traffic along the secretory and endocytic pathways is similarly …

The cancer drug discovery field has placed much emphasis on the identification of novel
and cancer-specific molecular targets. A rich source of such targets for the design of novel …

The zinc-ejecting aldehyde dehydrogenase (ALDH) inhibitory drug disulfiram (DSF) was
found to be a breast cancer-associated protein 2 (BCA2) inhibitor with potent antitumor …

Dithiocarbamates are a class of metal-chelating compounds with various applications in
medicine. They have been used for the treatment of bacterial and fungal infections, possible …

Breast cancer is one of the most common malignancies in females. It is an etiologically
complex disease driven by a multitude of cellular pathways. The proliferation and spread of …

Summary Valosin-containing protein (VCP)/p97 is an AAA-ATPase that extracts
polyubiquitinated substrates from multimeric macromolecular complexes and biological …

The subcellular localization and intracellular trafficking of Toll‐like receptors (TLRs) critically
regulate TLRs‐mediated antimicrobial immunity and autoimmunity. Here, it is demonstrated …