Immunotherapy has revolutionized cancer treatment and revitalized efforts to harness the
power of the immune system to combat a variety of cancer types more effectively. However …

Solid tumors are composed of a highly complex and heterogenic microenvironment, with
increasing metabolic status. This environment plays a crucial role in the clinical therapeutic …

Cancer is a leading cause of human death worldwide, and the modulation of the metabolic
properties of T cells employed in cancer immunotherapy holds great promise for combating …

Induction of apoptosis represents a promising therapeutic approach to drive tumor cells to
death. However, this poses challenges due to the intricate nature of cancer biology and the …

Background Clear cell renal cell carcinoma is a prototypical tumor characterized by
metabolic reprogramming, which extends beyond tumor cells to encompass diverse cell …

Cancer as an uncontrolled growth of cells due to existing mutation in host cells that may
proliferate, induce angiogenesis and sometimes metastasize due to the favorable tumor …

Oncolytic virus immunotherapy as a new tumor therapy has made remarkable achievements
in clinical practice. And metabolic reprogramming mediated by oncolytic virus has a …

Multiple myeloma (MM) is malignant disease characterized by the clonal proliferation of
plasma cells in the bone marrow, leading to anemia, immunosuppression, and other …

Background Pancreatic adenocarcinoma (PAAD) is a malignant tumor with a high mortality
rate. Methylation modifications acted a crucial role to affect cancer progression. The current …

T cells play a critical role in anti-tumor immunity, yet CD8 T cells often become dysfunctional
and/or exhausted during tumor progression. Tumor cells can promote CD8 T cell exhaustion …