Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …

Spleen tyrosine kinase (Syk) is a cytosolic non-receptor protein tyrosine kinase (PTK) and is
mainly expressed in hematopoietic cells. Syk was recognized as a critical element in the B …

Fatty acids (FAs) are essential nutrients, but how they are transported into cells remains
unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in …

Accurate ranking of compounds with regards to their binding affinity to a protein using
computational methods is of great interest to pharmaceutical research. Physics-based free …

Tyrosine kinases relay signals from diverse leukocyte antigen receptors, innate immune
receptors, and cytokine receptors, and therefore mediate the recruitment and activation of …

During the past 5 years, a number of highly active novel agents, including kinase inhibitors
targeting BTK or PI3Kδ, an antagonist of the antiapoptotic protein BCL-2, and new anti …

In both academia and the pharmaceutical industry, innovative hypotheses, methodologies
and technologies that can shorten the drug research and development, leading to higher …

Small-molecule inhibitors of kinases involved in B-cell receptor signaling are an important
advance in managing lymphoid malignancies. Entospletinib (GS-9973) is an oral, selective …

Free energy calculations are rapidly becoming indispensable in structure-enabled drug
discovery programs. As new methods, force fields, and implementations are developed …

Although agents targeting B-cell receptor signaling have provided practice-changing results
in relapsed chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL), they …