Immunotherapy has revolutionized cancer treatment and rejuvenated the field of tumor
immunology. Several types of immunotherapy, including adoptive cell transfer (ACT) and …

While immune checkpoint inhibitors (ICIs) have ushered in major changes in standards of
care for many solid tumor malignancies, primary and acquired resistance is common …

Genetically engineered T cells are powerful new medicines, offering hope for curative
responses in patients with cancer. Chimaeric antigen receptors (CARs) are a class of …

Adoptive cell therapy (ACT) utilizing either tumor-infiltrating lymphocyte (TIL)-derived T cells
or T cells genetically engineered to express tumor recognizing receptors has emerged as a …

T cells have the capacity to eradicate diseased cells, but tumours present considerable
challenges that render T cells ineffectual. Cancer cells often make themselves …

Purpose: Adoptive T-cell immunotherapy with tumor infiltrating lymphocytes or genetically-
modified T cells has yielded dramatic results in some cancers. However, T cells need to …

T cell-based adoptive immunotherapy has been shown to be a promising treatment for
various types of cancer. However, adoptive T cell therapy currently requires the custom …

The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …

Adoptive transfer of T lymphocytes is a promising treatment for a variety of malignancies but
often not feasible due to difficulties generating T cells that are reactive with the targeted …

Expression of native transgenic T cell receptors in recipient human T cells is often
insufficient to achieve highly reactive T cell bulks. Here we show that codon modification of …