T cell immunotherapy remains an attractive approach for cancer immunotherapy. T cell
immunotherapy mainly employs chimeric antigen receptor (CAR)-and T cell receptor (TCR) …

Simple Summary This review is intended to provide an overview on the history and recent
advances of T cell and natural killer (NK) cell-based immunotherapy. While the thymus was …

Immunotherapy is emerging as a promising avenue in oncology, gaining increasing
importance and offering substantial advantages when compared to chemotherapy or …

Artificial T-cell receptors are generated by joining an Ag-recognizing domain (ectodomain)
to the transmembrane and intracellular portion of a signaling molecule (endodomain). The …

Building on the principals that the adoptive transfer of T cells can lead to the regression of
established tumors in humans, investigators are now further manipulating these cells using …

Adoptive cell transfer (ACT) using T cell receptor (TCR) gene-modified T cells is an exciting
and rapidly evolving field. Numerous preclinical and clinical studies have demonstrated …

Effective T cell receptor (TCR) transfer until now required stable retroviral transduction.
However, retroviral transduction poses the threat of irreversible genetic manipulation of …

The HIV-specific cytotoxic T lymphocyte (CTL) response is a critical component in controlling
viral replication in vivo, but ultimately fails in its ability to eradicate the virus. Our intent in …

In recent years, the interest in using messenger RNA (mRNA) as a therapeutic means to
tackle different diseases has enormously increased. This holds true not only for numerous …

Patients with diseases characterized by chronic inflammation, caused by infection or cancer,
have T cells and NK cells with impaired function. The underlying molecular mechanisms are …