Adoptive transfer of antigen-specific CD4+ and CD8+ T cells is one of the most efficient
forms of cancer immunotherapy. However, the isolation of antigen-specific CD4+ T cells is …

Reactivation of CMV can cause severe disease after allogeneic hemopoietic stem cell
transplantation. Adoptive T cell therapy was successfully used for patients who had received …

An effective immune response against cancer requires the activation and expansion of
specific T cells. Tumor antigens, however, are generally poor immunogens. To achieve …

Adoptive transfer of T lymphocytes is a promising therapy for malignancies—particularly of
the hemopoietic system—and for otherwise intractable viral diseases. Efforts to broaden the …

Post-transplant lymphoproliferative disease (PTLD) refers to a collection of clinically and
pathologically diverse tumours associated with iatrogenic immunosuppression following …

Background We have treated three patients with carboxy-anhydrase-IX (CAIX) positive
metastatic renal cell cancer (RCC) by adoptive transfer of autologous T-cells that had been …

A recent phase 1 trial has demonstrated that the generation of tumor-reactive T lymphocytes
by transfer of specific T-cell receptor (TCR) genes into autologous lymphocytes is feasible …

T cells engineered to express a tumor-specific αβ T cell receptor (TCR) mediate anti-tumor
immunity. However, mispairing of the therapeutic αβ chains with endogenous αβ chains …

Adoptive immunotherapy of cancer requires the generation of large numbers of tumor
antigen–reactive T cells for transfer into cancer patients. Genes encoding tumor antigen …

Advancement in our understanding of immune cell recognition and emerging cellular
engineering technologies during the last decades made active manipulation of the T cell …