Tumor antigen–specific CD4+ and CD8+ T lymphocytes, especially interferon-γ (IFN-γ)–
producing type-1 helper T (Th1) and type-1 cytotoxic T (Tc1) cells, play a crucial role in …

The T‐cell receptor (TCR) is critical for T‐cell lineage selection, antigen specificity, effector
function and survival. Recently, TCR gene transfer has been developed as a reliable …

The identification of novel tumor antigens is of extreme importance for effective
immunotherapy against cancer. A major obstacle in this field is the limited life span of tumor …

Endowing T lymphocytes with novel functional attributes by genetic modification is under
development for a broad range of clinical cellular immunotherapy applications. To …

In preparation of a clinical phase I/II study in renal cell carcinoma (RCC) patients, we
developed a clinically applicable protocol that meets good clinical practice (GCP) criteria …

Immunotherapy is one of the most promising and innovative approaches to treat cancer, viral
infections, and other immune-modulated diseases. Adoptive immunotherapy using gene …

T-cell receptor (TCR) allorecognition is often presumed to be relatively nonspecific,
attributable to either a TCR focus on exposed major histocompatibility complex (MHC) …

Abstract Targeting B7-H3 over-expressed tumor cells with anti-B7-H3 monoclonal
antibodies inhibits tumor growth. Here we demonstrated the expression of B7 family …

Adoptive transfer of T-cell receptor (TCR) genes has been proposed as an attractive
approach for immunotherapy in cases where the endogenous T-cell repertoire is insufficient …

Alpha-fetoprotein (AFP) is overexpressed in hepatocellular carcinoma (HCC) and could
serve as a tumor-associated antigen (TAA) and potential target for adoptive immunotherapy …