Improving and accelerating bone repair still are partially unmet needs in bone regenerative
therapies. In this regard, strontium (Sr)-containing bioactive glasses (BGs) are highly …

Treatment of bone defects caused by trauma or disease is a major burden on human
healthcare systems. Although autologous bone grafts are considered as the gold standard …

Critical-size bone defects are an important problem in clinical practice, which usually occurs
in severe trauma, or tumor resection, and cannot heal completely and autonomously …

The regeneration capacity of the osteoporotic bones is generally lower than that of the
normal bones. Current methods of bone defect treatment for osteoporosis are not always …

The chemical composition, structure and surface characteristics of biomaterials/scaffold can
affect the adsorption of proteins, and this in turn influences the subsequent cellular response …

For the clinical application of bone tissue engineering with the combination of biomaterials
and mesenchymal stem cells (MSCs), bone scaffolds should possess excellent …

Immune responses are vital for bone regeneration and play an essential role in the fate of
biomaterials after implantation. As a kind of plastic cell, macrophages are central regulators …

Extrusion-based bioprinting, also known as 3D bioplotting, is a powerful tool for the
fabrication of tissue equivalents with spatially defined cell distribution. Even though …

Numerous studies have demonstrated that calcium silicate (CS) can be doped with various
trace metal elements such as strontium (Sr) or magnesium (Mg). These studies have …

Vascularized bone tissue engineering is regarded as one of the optimal treatment options
for large bone defects. The lack of angiogenic properties and unsatisfactory …