The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Salt and fluid absorption and secretion are two processes that are fundamental to epithelial
function and whole body fluid homeostasis, and as such are tightly regulated in epithelial …

This comprehensive State of the Art review summarizes the current published knowledge
base regarding the pathophysiology and microbiology of pulmonary disease in cystic …

Submucosal glands contribute to airway surface liquid (ASL), a film that protects all airway
surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B …

With the improving survival of patients with cystic fibrosis (CF), the clinical spectrum of this
complex multisystem disease continues to evolve. One of the most important clinical events …

Mucus is essential for protection of the airways; however, in chronic airway disease mucus
hypersecretion is an important factor in morbidity and mortality. The properties of the mucus …

Mucus pathology in cystic fibrosis (CF) has been known for as long as the disease has been
recognized and is sometimes called mucoviscidosis. The disease is marked by mucus …

Mammalian airways normally regulate the volume of a thin liquid layer, the periciliary liquid
(PCL), to facilitate the mucus clearance component of lung defense. Studies under standard …

Airway disease currently causes most of the morbidity and mortality in patients with cystic
fibrosis (CF). However, understanding the pathogenesis of CF lung disease and developing …

We demonstrate the use of a high resolution form of optical coherence tomography, termed
micro-OCT (μOCT), for investigating the functional microanatomy of airway epithelia. μOCT …