[HTML][HTML] Recent advances of ferroptosis in tumor: From biological function to clinical application

S Hu, Y Chu, X Zhou, X Wang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Ferroptosis is a recently recognized form of cell death with distinct features in terms of
morphology, biochemistry, and molecular mechanisms. Unlike other types of cell death …

Inside PD-1/PD-L1, 2 with their inhibitors

N Boisgerault, P Bertrand - European Journal of Medicinal Chemistry, 2023 - Elsevier
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Drug repurposing to enhance antitumor response to PD-1/PD-L1 immune checkpoint inhibitors

X Thuru, R Magnez, H El-Bouazzati, G Vergoten… - Cancers, 2022 - mdpi.com
Simple Summary Novel pharmacological approaches are needed to improve treatments of
advanced cancers, despite the considerable benefit of immunotherapy. New drugs are …

Molecular mechanisms of chloroquine and hydroxychloroquine used in cancer therapy

JB De Sanctis, J Charris, Z Blanco… - Anti-Cancer Agents …, 2023 - ingentaconnect.com
Tumour relapse, chemotherapy resistance, and metastasis continue to be unsolved issues
in cancer therapy. A recent approach has been to scrutinise drugs used in the clinic for other …

Molecular Docking and Dynamics Simulation Revealed Ivermectin as Potential Drug against Schistosoma-Associated Bladder Cancer Targeting Protein Signaling …

AJ Siddiqui, MF Khan, WS Hamadou, M Goyal… - Medicina, 2021 - mdpi.com
Urogenital schistosomiasis is caused by Schistosoma haematobium (S. haematobium)
infection, which has been linked to the development of bladder cancer. In this study, three …

Therapeutic targeting of nuclear export and import receptors in cancer and their potential in combination chemotherapy

S Newell, PJ van der Watt, VD Leaner - IUBMB life, 2024 - Wiley Online Library
Systemic modalities are crucial in the management of disseminated malignancies and liquid
tumours. However, patient responses and tolerability to treatment are generally poor and …

Albendazole induces an anti-tumor effect and potentiates PD-L1 blockade immunotherapy

W Zhang, Z He, F Liang, J Gong, L Tan, J Yang… - Journal of Cancer …, 2023 - Springer
Background Previously, albendazole (ABZ) has been reported as an anti-parasitic drug
rather than anti-tumor drug. Our study aim to investigate whether ABZ also has a potential …

Bioactive microbial metabolites in cancer therapeutics: mining, repurposing, and their molecular targets

S Pattnaik, M Imchen, R Kumavath, R Prasad… - Current microbiology, 2022 - Springer
The persistence and resurgence of cancer, characterized by abnormal cell growth and
differentiation, continues to be a serious public health concern critically affecting public …

Re‐examining the evidence that ivermectin induces a melanoma‐like state in Xenopus embryos

A Hutchison, C Sibanda, M Hulme, S Anwar, B Gur… - …, 2024 - Wiley Online Library
Modeling metastasis in animal systems has been an important focus for developing cancer
therapeutics. Xenopus laevis is a well‐established model, known for its use in identifying …

Polyaromatic Bis(indolyl)methane Derivatives with Antiproliferative and Antiparasitic Activity

RCR Gonçalves, P Peñalver, SPG Costa, JC Morales… - Molecules, 2023 - mdpi.com
Bis (indolyl) methanes (BIMs) are a class of compounds that have been recognized as an
important core in the design of drugs with important pharmacological properties, such as …