Imidazole was first synthesized by Heinrich Debus in 1858 and was obtained by the reaction
of glyoxal and formaldehyde in ammonia, initially called glyoxaline. The current literature …

The cardiovascular and other actions of angiotensin II (Ang II) are mediated by AT1 and AT2
receptors, which are seven transmembrane glycoproteins with 30% sequence similarity …

Through the use of Pd2 (dba) 3/P (t-Bu) 3 as a catalyst, a wide range of aryl and vinyl
halides, including chlorides, undergo Suzuki cross-coupling with arylboronic acids in very …

Blockade of the renin-angiotensin system began as a way of studying the pathogenesis of
cardiovascular disease with specific pharmacological probes. Oral activity, achieved by …

Angiotensin II receptor blockers (ARBs) represent a new class of effective and well tolerated
orally active antihypertensive agents. Recent clinical trials have shown the added benefits of …

The application of pharmacogenetics holds great promise for individualized therapy.
However, it has little clinical reality at present, despite many claims. The main problem is that …

Losartan is the first orally available angiotensin-receptor antagonist without agonist
properties. Following oral administration, losartan is rapidly absorbed, reaching maximum …

Synopsis Valsartan competitively and selectively inhibits the actions of angiotensin II at the
AT 1 receptor subtype which is responsible for most of the known effects of angiotensin II. In …

Abstract The Carbon‐Nitrogen bond formation has always been an important and useful tool
in drug discovery. Its wide applications in synthesizing N‐heterocycles, known as the most …

Numerous drugs have the potential to adversely influence a patient's sense of taste, either
by decreasing function or producing perceptual distortions or phantom tastes. In some …