New twists in detecting mRNA modification dynamics
Modified nucleotides in mRNA are an essential addition to the standard genetic code of four
nucleotides in animals, plants, and their viruses. The emerging field of epitranscriptomics …
nucleotides in animals, plants, and their viruses. The emerging field of epitranscriptomics …
Translational control in virus-infected cells
N Stern-Ginossar, SR Thompson… - Cold Spring …, 2019 - cshperspectives.cshlp.org
As obligate intracellular parasites, virus reproduction requires host cell functions. Despite
variations in genome size and configuration, nucleic acid composition, and their repertoire of …
variations in genome size and configuration, nucleic acid composition, and their repertoire of …
2′-O-Methylation of the second transcribed nucleotide within the mRNA 5′ cap impacts the protein production level in a cell-specific manner and contributes to …
K Drazkowska, R Tomecki, M Warminski… - Nucleic acids …, 2022 - academic.oup.com
In mammals, m7G-adjacent nucleotides undergo extensive modifications. Ribose of the first
or first and second transcribed nucleotides can be subjected to 2′-O-methylation to form …
or first and second transcribed nucleotides can be subjected to 2′-O-methylation to form …
[HTML][HTML] Better together: the role of IFIT protein–protein interactions in the antiviral response
HV Mears, TR Sweeney - Journal of General Virology, 2018 - microbiologyresearch.org
The interferon-induced proteins with tetratricopeptide repeats (IFITs) are a family of antiviral
proteins conserved throughout all vertebrates. IFIT1 binds tightly to non-self RNA …
proteins conserved throughout all vertebrates. IFIT1 binds tightly to non-self RNA …
IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA
RC Fleith, HV Mears, XY Leong, TJ Sanford… - Nucleic acids …, 2018 - academic.oup.com
Interferon-induced proteins with tetratricopeptide repeats (IFITs) are highly expressed during
the cell-intrinsic immune response to viral infection. IFIT1 inhibits translation by binding …
the cell-intrinsic immune response to viral infection. IFIT1 inhibits translation by binding …
Zoonotic potential of emerging paramyxoviruses: knowns and unknowns
The risk of spillover of enzootic paramyxoviruses and the susceptibility of recipient human
and domestic animal populations are defined by a broad collection of ecological and …
and domestic animal populations are defined by a broad collection of ecological and …
Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations
YM Abbas, BT Laudenbach… - Proceedings of the …, 2017 - National Acad Sciences
IFIT1 (IFN-induced protein with tetratricopeptide repeats-1) is an effector of the host innate
immune antiviral response that prevents propagation of virus infection by selectively …
immune antiviral response that prevents propagation of virus infection by selectively …
ETV7 limits antiviral gene expression and control of influenza viruses
HM Froggatt, AT Harding, RR Chaparian… - Science signaling, 2021 - science.org
The type I interferon (IFN) response is an important component of the innate immune
response to viral infection. Precise control of IFN responses is critical because insufficient …
response to viral infection. Precise control of IFN responses is critical because insufficient …
[HTML][HTML] Mechanistic insight into long noncoding RNAs and the placenta
Long non-coding RNAs (lncRNAs) are classified as RNAs greater than 200 nucleotides in
length that do not produce a protein product. lncRNAs are expressed with cellular and …
length that do not produce a protein product. lncRNAs are expressed with cellular and …
[HTML][HTML] Influenza A virus inhibits RSV infection via a two-wave expression of IFIT proteins
Y Drori, J Jacob-Hirsch, R Pando… - Viruses, 2020 - mdpi.com
Influenza viruses and respiratory syncytial virus (RSV) are respiratory viruses that primarily
circulate worldwide during the autumn and winter seasons. Seasonal surveillance has …
circulate worldwide during the autumn and winter seasons. Seasonal surveillance has …