Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium)-induced hepatotoxicity–A review

K Renu, R Chakraborty, H Myakala, R Koti… - Chemosphere, 2021 - Elsevier
Heavy metals pose a serious threat if they go beyond permissible limits in our bodies. Much
heavy metal's viz. Lead, Chromium, Arsenic, Mercury, Nickel, and Cadmium pose a serious …

[HTML][HTML] An update of Nrf2 activators and inhibitors in cancer prevention/promotion

F Pouremamali, A Pouremamali, M Dadashpour… - Cell Communication and …, 2022 - Springer
Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …

[HTML][HTML] Post-treatment With Irisin Attenuates Acute Kidney Injury in Sepsis Mice Through Anti-Ferroptosis via the SIRT1/Nrf2 Pathway

Z Qiongyue, Y Xin, P Meng, M Sulin, W Yanlin… - Frontiers in …, 2022 - frontiersin.org
Kidney is one of the most vulnerable organs in sepsis, resulting in sepsis-associated acute
kidney injury (SA-AKI), which brings about not only morbidity but also mortality of sepsis …

From nature to therapy: Luteolin's potential as an immune system modulator in inflammatory disorders

MS Hussain, G Gupta, A Goyal, R Thapa… - … of biochemical and …, 2023 - Wiley Online Library
Inflammation is an essential immune response that helps fight infections and heal tissues.
However, chronic inflammation has been linked to several diseases, including cancer …

Dietary melatonin attenuates chromium-induced lung injury via activating the Sirt1/Pgc-1α/Nrf2 pathway

B Han, S Li, Y Lv, D Yang, J Li, Q Yang, P Wu, Z Lv… - Food & function, 2019 - pubs.rsc.org
Exposure to chromium (Cr) causes a number of respiratory diseases, including lung cancer
and pulmonary fibrosis. However, there is currently no safe treatment for Cr-induced lung …

[HTML][HTML] Regulation of Nrf2/ARE pathway by dietary flavonoids: a friend or foe for cancer management?

T L. Suraweera, HPV Rupasinghe, G Dellaire, Z Xu - Antioxidants, 2020 - mdpi.com
The nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE)
pathway is an important cell signaling mechanism in maintaining redox homeostasis in …

Protective effects of morin against acrylamide-induced hepatotoxicity and nephrotoxicity: A multi-biomarker approach

FM Kandemir, S Yıldırım, S Kucukler… - Food and chemical …, 2020 - Elsevier
Acrylamide (ACR) is a heat-induced carcinogen substance that is found in some foods due
to cooking or other thermal processes. The aim of present study was to assess the probable …

Rutin ameliorates mercuric chloride-induced hepatotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis

C Caglayan, FM Kandemir, E Darendelioğlu… - Journal of Trace …, 2019 - Elsevier
Objective Mercury is a global environmental pollutant and is responsible for several organ
pathophysiology including oxidative stress-induced liver disorders. Therefore, the present …

Toxicological effects of deltamethrin on quail cerebrum: weakened antioxidant defense and enhanced apoptosis

J Li, H Jiang, P Wu, S Li, B Han, Q Yang, X Wang… - Environmental …, 2021 - Elsevier
Deltamethrin is the most common type II synthetic pyrethroid insecticide, and has posed
widespread residues to environment. However, whether deltamethrin has potential toxic …

[HTML][HTML] Galangin Reverses H2O2-Induced Dermal Fibroblast Senescence via SIRT1-PGC-1α/Nrf2 Signaling

JJ Lee, SC Ng, JY Hsu, H Liu, CJ Chen… - International Journal of …, 2022 - mdpi.com
UV radiation and H2O2 are the primary factors that cause skin aging. Both trigger oxidative
stress and cellular aging. It has been reported that deacetylase silent information regulator 1 …