Gamma‐delta (γδ) T cell‐derived cytokines (IL‐4, IL‐17, IFN‐γ and IL‐10) and their possible implications for atopic dermatitis development

BO Fagundes, TR de‐Sousa… - International Journal of …, 2023 - Wiley Online Library
Atopic dermatitis (AD) is a chronic disease related to skin disorders that affect individuals in
their childhood and can persist or start in adulthood. Patients affected by this disease …

IgG from Adult Atopic Dermatitis (AD) Patients Induces Nonatopic Neonatal Thymic Gamma–Delta T Cells (γδT) to Acquire IL-22/IL-17 Secretion Profile with Skin …

BO Fagundes, TR de Sousa, A Nascimento… - International Journal of …, 2022 - mdpi.com
γδT cells mature in the human thymus, and mainly produce IL-17A or IFN-γ, but can also
produce IL-22 and modulate a variety of immune responses. Here, we aimed to evaluate …

IgG from adult atopic dermatitis (AD) patients induces thymic IL-22 production and CLA expression on CD4+ T cells: Possible epigenetic implications mediated by …

TR de Sousa, BO Fagundes, A Nascimento… - International Journal of …, 2022 - mdpi.com
Atopic dermatitis (AD) is a common relapsing inflammatory skin disorder characterized by
immune-mediated inflammation and epidermal barrier dysfunction. The pathogenesis of AD …

The Mysterious Actor—γδ T Lymphocytes in Chronic Lymphocytic Leukaemia (CLL)

MK Zarobkiewicz, AA Bojarska-Junak - Cells, 2022 - mdpi.com
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia among adults. It is the
clonal expansion of B cells expressing CD19 and CD5. Despite significant progress in …

Differential modulation of IL-4, IL-10, IL-17, and IFN-γ production mediated by IgG from Human T-lymphotropic virus-1 (HTLV-1) infected patients on healthy peripheral …

NR Machado, BO Fagundes, LA Fernandes… - Frontiers in …, 2023 - frontiersin.org
Human T-lymphotropic virus 1 (HTLV-1) infected individuals remain as asymptomatic
carriers (ACs) or can develop the chronic neurological disorder HTLV-1-associated …

Innate immune cell activation after HIV-1 vaccine administration is associated with increased antibody production

KF N'guessan, K Machmach, I Swafford… - Frontiers in …, 2024 - frontiersin.org
The RV144 Thai phase III clinical trial's canarypox–protein HIV vaccine regimen showed
modest efficacy in reducing infection. We therefore sought to determine the effects of vaccine …

Lymphopenia in COVID-19: γδ T Cells-based therapeutic opportunities

E Lo Presti, F Dieli, S Meraviglia - Vaccines, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection dysregulates the
immune system by lymphopenia of B cells, monocytes, eosinophils, basophils, and cytotoxic …

Non-atopic neonatal thymic innate lymphoid cell subsets (ILC1, ILC2, and ILC3) identification and the modulatory effect of IgG from dermatophagoides pteronyssinus …

TR de Sousa, FR Sgnotto, BO Fagundes… - Frontiers in …, 2021 - frontiersin.org
Innate lymphoid cells (ILCs) are classified into distinct subsets termed ILC1, ILC2, and ILC3
cells. The existing literature lacks evidence identifying ILCs and their subsets in the human …

Genomic Medicine and Advances in Vaccine Technology and Development in the Developing and Developed World

R Cianci, L Franza - Vaccines, 2020 - mdpi.com
Vaccinations are one of the most effective public health measures available at present. Yet,
a growing skepticism surrounding vaccinations is causing a lower vaccination rate than …

Preconceptional Immunization Can Modulate Offspring Intrathymic IL-17-Producing γδT Cells with Epigenetic Implications Mediated by microRNAs

TR de-Sousa, R Pessôa, A Nascimento… - International Journal of …, 2021 - mdpi.com
The mechanisms through which maternal immunization can modulate offspring thymic
maturation of lymphocytes are not fully understood. Here, we aimed to evaluate whether …