Mutations of key driver genes in colorectal cancer progression and metastasis
D Huang, W Sun, Y Zhou, P Li, F Chen, H Chen… - Cancer and Metastasis …, 2018 - Springer
The association between mutations of key driver genes and colorectal cancer (CRC)
metastasis has been investigated by many studies. However, the results of these studies …
metastasis has been investigated by many studies. However, the results of these studies …
[HTML][HTML] Colorectal carcinogenesis-update and perspectives
H Raskov, HC Pommergaard, J Burcharth… - World journal of …, 2014 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is a very common malignancy in the Western World and despite
advances in surgery, chemotherapy and screening, it is still the second leading cause of …
advances in surgery, chemotherapy and screening, it is still the second leading cause of …
[HTML][HTML] The heterogeneous clinical and pathological landscapes of metastatic Braf-mutated colorectal cancer
GN Fanelli, CA Dal Pozzo, I Depetris, M Schirripa… - Cancer Cell …, 2020 - Springer
Colorectal cancer (CRC) is a complex and molecularly heterogeneous disease representing
one of the most frequent causes of cancer-related death worldwide. About 8–15% of CRCs …
one of the most frequent causes of cancer-related death worldwide. About 8–15% of CRCs …
[HTML][HTML] RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis
Serrated pathway colorectal cancers (CRCs) are characterised by a BRAF mutation and half
display microsatellite instability (MSI). The Wnt pathway is commonly upregulated in …
display microsatellite instability (MSI). The Wnt pathway is commonly upregulated in …
How the BRAF V600E Mutation Defines a Distinct Subgroup of Colorectal Cancer: Molecular and Clinical Implications
CE Bond, VLJ Whitehall - Gastroenterology research and …, 2018 - Wiley Online Library
The BRAF oncogene is an integral component of the MAP kinase pathway, and an activating
V600E mutation occurs in 15% of sporadic colorectal cancer. This is an early event in …
V600E mutation occurs in 15% of sporadic colorectal cancer. This is an early event in …
MSI status is associated with distinct clinicopathological features in BRAF mutation colorectal cancer: A systematic review and meta-analysis
M Wu, YS Kim, HS Ryu, SC Choi, KY Kim… - … -Research and Practice, 2020 - Elsevier
Abstract Background Microsatellite stable (MSS) BRAF p. V600E mutation colorectal cancer
(BRAF-CRC) has a poor prognosis, whereas microsatellite instability (MSI) in BRAF-CRC is …
(BRAF-CRC) has a poor prognosis, whereas microsatellite instability (MSI) in BRAF-CRC is …
[HTML][HTML] BRAF-mutated colorectal adenocarcinomas: Pathological heterogeneity and clinical implications
V Angerilli, G Sabella, G Centonze, S Lonardi… - Critical Reviews in …, 2022 - Elsevier
Advances in molecular biology have markedly increased our understanding of the
heterogeneous molecular landscape of colorectal cancer (CRC). Up to 15% of CRCs harbor …
heterogeneous molecular landscape of colorectal cancer (CRC). Up to 15% of CRCs harbor …
Association between baseline circulating tumor cells, molecular tumor profiling, and clinical characteristics in a large cohort of chemo-naïve metastatic colorectal …
J Sastre, V de la Orden, A Martínez, I Bando… - Clinical Colorectal …, 2020 - Elsevier
Background Clinicopathologic characteristics and prognostic and predictive factors offer
valuable guidance when selecting optimal first-line treatment in patients with metastatic …
valuable guidance when selecting optimal first-line treatment in patients with metastatic …
Evolutionary patterns of chromosomal instability and mismatch repair deficiency in proximal and distal colorectal cancer
MM Golas, B Gunawan, M Cakir, S Cameron… - Colorectal …, 2022 - Wiley Online Library
Abstract Aim Colorectal carcinomas (CRCs) progress through heterogeneous pathways.
The aim of this study was to analyse whether or not the cytogenetic evolution of CRC is …
The aim of this study was to analyse whether or not the cytogenetic evolution of CRC is …
[PDF][PDF] BRAF mutation: Current and future clinical pathological applications in colorectal carcinoma
JY Ng, CT Lu, AK Lam - Histol. Histopathol, 2019 - hh.um.es
The aims are to review the relevance of the BRAF mutations in the clinical settings of
colorectal carcinoma. All the literature concerning BRAF mutations and colorectal carcinoma …
colorectal carcinoma. All the literature concerning BRAF mutations and colorectal carcinoma …