Polyphenols constitute an important group of natural products that are traditionally
associated with a wide range of bioactivities. These are usually found in low concentrations …

Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses among all
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …

Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of
the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 …

One of the most prevalent and lethal forms of gynecological cancer is ovarian cancer (OC),
which is often diagnosed in its latter, deadly stages. The OC's high mortality and …

Although pancreatic cancer (PC) was considered in the past an orphan cancer type due to
its low incidence, it may become in the future one of the leading causes of cancer death …

Abstract Phosphoinositide-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
signaling pathway is one of the most important proliferative signaling pathways with critical …

NF-κB transcription factors are critical regulators of innate and adaptive immunity and major
mediators of inflammatory signaling. The NF-κB signaling is dysregulated in a significant …

Matrine is an alkaloid isolated from the traditional Chinese medicine Sophora flavescens
Aiton. At present, a large number of studies have proved that matrine has an anticancer …

Purpose: Here, we have investigated treatment resistance mechanisms in small cell lung
cancer (SCLC) by focusing on comparing the genotype and phenotype in tumor samples of …

Cancer therapy through anticancer drugs and radiotherapy is associated with several side
effects as well as tumor resistance to therapy. The genotoxic effects of chemotherapy and …