A laser-based hydrogel degradation technique was developed that allowed for local control
over hydrogel porosity; fabrication of 3D vascular-derived, biomimetic, hydrogel-embedded …

The extracellular matrix (ECM) is a critical cue to direct tumorigenesis and metastasis.
Although two-dimensional (2D) culture models have been widely employed to understand …

Non-small cell lung cancer (NSCLC) is a global disorder, treatment options for which remain
limited with resistance development by cancer cells and off-target events being major …

Microphysiological systems have emerged in the last decade to provide an alternative to in
vivo models in basic science and pharmaceutical research. In the field of vascular biology, in …

Simple Summary Growth factors promote angiogenesis, which is a critical process in the
development of tumors. One of the therapeutic techniques being investigated in the …

Abstract Background Cancer-associated fibroblasts (CAFs) are highly differentiated and
heterogeneous cancer-stromal cells that promote tumour growth, angiogenesis and matrix …

Cancer-associated fibroblast (CAF) secretes extracellular vesicle (EV)-encapsulated
microRNAs (miRNAs) which have been underlined great promise for therapeutic target for …

Tumor angiogenesis is critical to tumor growth and metastasis, yet much is unknown about
the role vascular cells play in the tumor microenvironment. In vitro models that mimic in vivo …

Stem cell-based therapy appears as a promising strategy to induce regeneration of
damaged and diseased tissues. However, low survival, poor engraftment and a lack of site …

Simple Summary The tumour microenvironment is composed of multiple non-cancerous
cells that communicate with the tumour cells, influencing their behaviour and impacting the …