Nanomedicine targeting ferroptosis to overcome anticancer therapeutic resistance

J Cai, X Xu, PE Saw - Science China Life Sciences, 2024 - Springer
A potential reason for the failure of tumor therapies is treatment resistance. Resistance to
chemotherapy, radiotherapy, and immunotherapy continues to be a major obstacle in clinic …

The roles of ferroptosis in cancer: tumor suppression, tumor microenvironment, and therapeutic interventions

G Lei, L Zhuang, B Gan - Cancer cell, 2024 - cell.com
In cancer treatment, the recurrent challenge of inducing apoptosis through conventional
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …

A multifunctional covalent organic framework nanozyme for promoting ferroptotic radiotherapy against esophageal cancer

LL Zhou, Q Guan, W Zhou, JL Kan, K Teng, M Hu… - ACS …, 2023 - ACS Publications
Radiotherapy is inevitably accompanied by some degree of radiation resistance, which
leads to local recurrence and even therapeutic failure. To overcome this limitation, herein …

Targeting Nrf2 for ferroptosis-based therapy: Implications for overcoming ferroptosis evasion and therapy resistance in cancer

J Lee, JL Roh - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2023 - Elsevier
Ferroptosis is a newly discovered form of programmed cell death caused by redox-active
iron-mediated lipid peroxidation. Ferroptosis exhibits a unique morphological phenotype …

Puerarin attenuates valproate-induced features of ASD in male mice via regulating Slc7a11-dependent ferroptosis

P Jiang, L Zhou, L Zhao, X Fei, Z Wang, T Liu… - …, 2024 - nature.com
Autism spectrum disorder (ASD) is a complicated, neurodevelopmental disorder
characterized by social deficits and stereotyped behaviors. Accumulating evidence suggests …

[HTML][HTML] Radiotherapy-induced ferroptosis for cancer treatment

GL Beretta, N Zaffaroni - Frontiers in Molecular Biosciences, 2023 - frontiersin.org
Ferroptosis is a regulated cell death mechanism controlled by iron, amino acid and reactive
oxygen species metabolisms, which is very relevant for cancer therapy. Radiotherapy …

Peptide‐Functionalized Inorganic Oxide Nanomaterials for Solid Cancer Imaging and Therapy

X Duan, P Wang, L He, Z He, S Wang… - Advanced …, 2024 - Wiley Online Library
The diagnosis and treatment of solid tumors have undergone significant advancements
marked by a trend toward increased specificity and integration of imaging and therapeutic …

Oxygen Vacancy‐Rich Manganese Nanoflowers as Ferroptosis Inducers for Tumor Radiotherapy

Y Liu, F Pi, L He, F Yang, T Chen - Small, 2024 - Wiley Online Library
The combination of ferroptosis and innovative tumor therapy methods offers another
promising answer to the problem of tumors. In order to generate effective ferroptosis in tumor …

From ferroptosis to cuproptosis, and calcicoptosis, to find more novel metals-mediated distinct form of regulated cell death

J Gu, C Guo, J Ruan, K Li, Y Zhou, X Gong, H Shi - Apoptosis, 2024 - Springer
Regulated cell death (RCD), also known as programmed cell death (PCD), plays a critical
role in various biological processes, such as tissue injury/repair, development, and …

Progress and challenges in tumor ferroptosis treatment strategies: a comprehensive review of metal complexes and nanomedicine

Y Su, B Liu, B Wang, L Chan, C Xiong, L Lu, X Zhang… - Small, 2024 - Wiley Online Library
Ferroptosis is a new form of regulated cell death featuring iron‐dependent lipid peroxides
accumulation to kill tumor cells. A growing body of evidence has shown the potential of …