Hypertension and hyperhomocysteinemia as modifiable risk factors for Alzheimer's disease and dementia: New evidence, potential therapeutic strategies, and …

A Carey, S Fossati - Alzheimer's & Dementia, 2023 - Wiley Online Library
This review summarizes recent evidence on how mid‐life hypertension,
hyperhomocysteinemia (HHcy) and blood pressure variability, as well as late‐life …

Dementia in former amateur and professional contact sports participants: population-based cohort study, systematic review, and meta-analysis

GD Batty, P Frank, UM Kujala, SJ Sarna… - …, 2023 - thelancet.com
Background Although there is growing evidence that former professional athletes from
sports characterised by repetitive head impact subsequently experience an elevated risk of …

Association of systolic blood pressure with dementia risk and the role of age, U-shaped associations, and mortality

JW van Dalen, C Brayne, PK Crane… - JAMA internal …, 2022 - jamanetwork.com
Importance The optimal systolic blood pressure (SBP) to minimize the risk of dementia in
older age is unknown. Objective To investigate whether the association between SBP and …

The relationship between midlife dyslipidemia and lifetime incidence of dementia: A systematic review and meta‐analysis of cohort studies

J Wee, S Sukudom, S Bhat, M Marklund… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction We conducted a systematic review and meta‐analysis to review the relationship
between midlife dyslipidemia and lifetime incident dementia. Methods The databases …

Sex differences in the association between cardiovascular diseases and dementia subtypes: a prospective analysis of 464,616 UK Biobank participants

C Dong, C Zhou, C Fu, W Hao, A Ozaki… - Biology of sex …, 2022 - Springer
Background Whether the association of cardiovascular diseases (CVDs) with dementia
differs by sex remains unclear, and the role of socioeconomic, lifestyle, genetic, and medical …

Age at menopause and all-cause and cause-specific dementia: a prospective analysis of the UK Biobank cohort

W Hao, C Fu, C Dong, C Zhou, H Sun… - Human …, 2023 - academic.oup.com
STUDY QUESTION Are there associations between natural or surgical menopause and
incident dementia by age at menopause? SUMMARY ANSWER Compared to age at …

Neuron-level explainable AI for Alzheimer's Disease assessment from fundus images

N Yousefzadeh, C Tran, A Ramirez-Zamora, J Chen… - Scientific Reports, 2024 - nature.com
Alzheimer's Disease (AD) is a progressive neurodegenerative disease and the leading
cause of dementia. Early diagnosis is critical for patients to benefit from potential intervention …

Burden of illness in people with Alzheimer's disease: a systematic review of epidemiology, comorbidities and mortality

KL Lanctôt, JH Hahn-Pedersen, CS Eichinger… - The Journal of …, 2024 - Springer
Background Alzheimer's disease (AD) is the most common neurodegenerative disease
worldwide, and an updated quantification of its impact on morbidity, disability, and mortality …

South Asian, Black and White ethnicity and the effect of potentially modifiable risk factors for dementia: A study in English electronic health records

N Mukadam, L Marston, G Lewis, R Mathur, E Lowther… - Plos one, 2023 - journals.plos.org
Introduction We aimed to investigate ethnic differences in the associations of potentially
modifiable risk factors with dementia. Methods We used anonymised data from English …

Diastolic blood pressure and intensive blood pressure control on cognitive outcomes: insights from the SPRINT MIND Trial

C Jiang, S Li, Y Wang, Y Lai, Y Bai, M Zhao, L He… - …, 2023 - Am Heart Assoc
Background: The potential benefits or harms of intensive systolic blood pressure (BP) control
on cognitive function and cerebral blood flow in individuals with low diastolic blood pressure …