Macrophage plasticity, polarization, and function in health and disease

A Shapouri‐Moghaddam… - Journal of cellular …, 2018 - Wiley Online Library
Macrophages are heterogeneous and their phenotype and functions are regulated by the
surrounding micro‐environment. Macrophages commonly exist in two distinct subsets: 1) …

[HTML][HTML] Immune defence to invasive fungal infections: A comprehensive review

B Pathakumari, G Liang, W Liu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
The fungal infections are relatively common in humans that can range from common, mild
superficial infections to life-threatening invasive infections. Most of the pathogenic fungi are …

Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer

J Qi, H Sun, Y Zhang, Z Wang, Z Xun, Z Li… - Nature …, 2022 - nature.com
Colorectal cancer (CRC) is among the most common malignancies with limited treatments
other than surgery. The tumor microenvironment (TME) profiling enables the discovery of …

Cryptococcus: from environmental saprophyte to global pathogen

RC May, NRH Stone, DL Wiesner, T Bicanic… - Nature Reviews …, 2016 - nature.com
Cryptococcosis is a globally distributed invasive fungal infection that is caused by species
within the genus Cryptococcus which presents substantial therapeutic challenges. Although …

Macrophage polarisation: an immunohistochemical approach for identifying M1 and M2 macrophages

MHM Barros, F Hauck, JH Dreyer, B Kempkes… - PloS one, 2013 - journals.plos.org
Macrophage polarization is increasingly recognised as an important pathogenetic factor in
inflammatory and neoplastic diseases. Proinflammatory M1 macrophages promote T helper …

Induction of memory-like dendritic cell responses in vivo

CR Hole, CML Wager, N Castro-Lopez… - Nature …, 2019 - nature.com
Dendritic cells (DCs), a vital component of the innate immune system, are considered to lack
antigen specificity and be devoid of immunological memory. Strategies that can induce …

The role of immune cells in recurrent spontaneous abortion

D Li, L Zheng, D Zhao, Y Xu, Y Wang - Reproductive Sciences, 2021 - Springer
Recurrent spontaneous abortion affects approximately 1–2% of women of childbearing, and
describes a condition in which women suffer from three or more continuous spontaneous …

Cryptococcus neoformans Infection in the Central Nervous System: The Battle between Host and Pathogen

Y Chen, ZW Shi, AB Strickland, M Shi - Journal of Fungi, 2022 - mdpi.com
Cryptococcus neoformans (C. neoformans) is a pathogenic fungus with a global distribution.
Humans become infected by inhaling the fungus from the environment, and the fungus …

Antifungal innate immunity: a perspective from the last 10 years

F Salazar, GD Brown - Journal of innate immunity, 2018 - karger.com
Fungal pathogens can rarely cause diseases in immunocompetent individuals. However,
commensal and normally nonpathogenic environmental fungi can cause life-threatening …

Cerebrospinal fluid cytokine profiles predict risk of early mortality and immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis

JN Jarvis, G Meintjes, T Bicanic, V Buffa… - PLoS …, 2015 - journals.plos.org
Understanding the host immune response during cryptococcal meningitis (CM) is of critical
importance for the development of immunomodulatory therapies. We profiled the …