Cryptococcus species, the etiological agents of cryptococcosis, are encapsulated fungal
yeasts that predominantly cause disease in immunocompromised individuals, and are …

Macrophages are key cellular components of innate immunity, acting as the first line of
defense against pathogens to modulate homeostatic and inflammatory responses. They …

Recurrent spontaneous abortion (RSA) is a common complication of early pregnancy.
Excessive M1 macrophage was found to be involved in RSA, but the underlying …

Human fungal infections have been on the rise in recent years and proved increasingly
difficult to treat as a result of the lack of diagnostics, effective antifungal therapies, and …

Immunocompromised individuals are at high risk of developing severe fungal infections with
high mortality rates, while fungal pathogens pose little risk to most healthy people. Poor …

Cryptococcus neoformans is a leading cause of invasive fungal infections among
immunocompromised patients. However, the cellular constituents of the innate immune …

Development of vaccines against opportunistic infections is difficult as patients most at risk of
developing disease are deficient in aspects of the adaptive immune system. Here, we …

The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in
immune compromised individuals. This pathogen is typically acquired via inhalation, and …

How lung macrophages, especially interstitial macrophages (IMs), respond to invading
pathogens remains elusive. Here, we show that mice exhibited a rapid and substantial …

We previously reported that administration of Cryptococcus neoformans Δsgl1 mutant
vaccine, accumulating sterylglucosides (SGs) and having normal capsule (GXM), protects …