Adenosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects
of extracellular ATP are mediated by plasma membrane receptors named P2 receptors …

Virtually, all tumor cells as well as all immune cells express plasma membrane receptors for
extracellular nucleosides (adenosine) and nucleotides (ATP, ADP, UTP, UDP and sugar …

Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …

P2X receptors are membrane ion channels that open in response to the binding of
extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40 …

P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …

Human health is under constant threat of a wide variety of dangers, both self and nonself.
The immune system is occupied with protecting the host against such dangers in order to …

ATP is a (co) transmitter and signaling molecule in the CNS. It acts at a multitude of ligand-
gated cationic channels termed P2X to induce rapid depolarization of the cell membrane …

Human IL-1 family proteins are key mediators of the host response to infections, injury, and
immunologic challenges. The mechanism by which IL-1 activates proinflammatory …

The proinflammatory cytokine interleukin-1β (IL-1β) is a secreted protein that lacks a signal
peptide and does not follow currently known pathways of secretion. Its efficient release from …

The P2X7 receptor is an ATP-gated ion channel known for its cytotoxic activity. However,
recent evidence suggests a role for P2X7 in cell proliferation. Here, we found that P2X7 …