The immune system is intimately involved in the pathophysiology of heart failure. However, it
is currently underused as a therapeutic target in the clinical setting. Moreover, the …

Background. Inflammation and oxidative stress are involved in the initiation and progress of
heart failure (HF). However, the role of the IL6/STAT3 pathway in the pressure overload …

Despite advances in medicine, cardiac disease remains an increasing health problem
associated with a high mortality rate. Maladaptive cardiac remodeling, such as cardiac …

Oxidative damage and accumulation of extracellular matrix (ECM) components play a
crucial role in the adverse outcome of cardiac hypertrophy. Evidence suggests that nuclear …

Hypertensive cardiac remodelling is a common cause of heart failure. However, the
molecular mechanisms regulating cardiac remodelling remain unclear. Pyruvate kinase …

Cardiac fibrosis critically injured the cardiac structure and function of the hypertensive
patients. However, the anti‐fibrotic strategy is still far from satisfaction. This study aims to …

Necroptosis is a programmed form of necrotic cell death. Necroptosis is regulated by the
necroptosis-regulating proteins including receptor-interacting protein (RIP) 1, RIP3, and …

A novel cage-based crystalline covalent organic framework, ie Cage-COF-TT (TT=
triammonia–terephthalaldehyde), was prepared from a prism-like triammonia-containing …

Abstract Ethnopharmacological relevance Optimized New Shengmai Powder (ONSMP) is a
traditional Chinese medicine (TCM) formula for heart failure treatment. MAPK signaling …

Human induced pluripotent stem cell (hiPSC)‐derived cardiac organoids (COs) have shown
great potential in modelling human heart development and cardiovascular diseases, a …