Due to the pro-survival effect of mild autophagy, the therapeutic effect of chemo-
immunotherapy is unsatisfactory. In addition, the adverse tumour microenvironment (TME) …

Colorectal cancer (CRC) has been the third most common malignancy and the second
cause of cancer-related mortality. As the core of volume-sensitive chloride currents, leucine …

Multiple sclerosis (MS) is a complex autoimmune disorder of the CNS that affects millions of
people worldwide. The causes of the disease remain unknown despite extensive efforts to …

Background Intrahepatic cholangiocarcinoma (ICC) accounts for about 15% of primary liver
cancer, and the incidence rate has been rising in recent years. Surgical resection is the best …

Primary testicular lymphoma (PTL) is a rare lymphoma predominantly occurring in the
elderly male population. It is characterized by a limited response to treatment and a …

Background Lymph node metastasis (LNM) is a prognostic biomarker and affects
therapeutic selection in colorectal cancer (CRC). Current evaluation methods are not …

Circular RNA (circRNA), a type of non‑coding RNA, plays a regulatory role in biological
processes. The special loop structure of circRNA makes it highly stable and specific in …

Background DNA walker-based strategies have gained significant attention in nucleic acid
analysis. However, they face challenges related to balancing design complexity, sequence …

The advancement of novel technologies, coupled with bioinformatics, has led to the
discovery of additional genes, such as long noncoding RNAs (lncRNAs), that are associated …

In the regulation of gene expression, epigenetic factors like non-coding RNAs (ncRNAs)
play an equal role in genetics. The role of microRNAs (miRNAs), which are members of the …