Alzheimer's disease (AD) is a very common neurodegenerative disorder associated with
memory loss and a progressive decline in cognitive activity. The two major …

In an effort to identify novel multifunctional drug candidates for the treatment of Alzheimer's
disease (AD), a series of hybrid molecules were synthesised by reacting N-(aminoalkyl) …

A convenient, one‐pot multi‐component methodology was developed for the preparation of
tetrahydro‐4H‐chromene and dihydropyrano [c] chromene derivatives as important …

A series of novel N-substituted α-aminophosphonates-bearing chromone moiety were
synthesized and evaluated for acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) …

On the basis of N-((5-(3-(1-benzylpiperidin-4-yl) propoxy)-1-methyl-1 H-indol-2-yl) methyl)-N-
methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have …

A series of novel tacrine-phenolic acid dihybrids and tacrine-phenolic acid-ligustrazine
trihybrids were synthesized, characterized and screened as novel potential anti-Alzheimer …

OBJECTIVE: Staphylococcus aureus-induced toxic shock syndrome (TSS) is a rare, but
potentially fatal disease with limited treatment options. The emergence of antibiotic-resistant …

Neurodegenerative disorders such as Alzheimer's (AD) and Parkinson's disease (PD)
usually starts gradually and progressively worsens, and are recognized as one of the …

The complex and multifactorial nature of neuropsychiatric diseases demands multi-target
drugs that can intervene with various sub-pathologies underlying disease progression …

The synthesis, pharmacological analysis and molecular modeling of the readily available
racemic tacrine analogs 21–30, bearing the 7-aryl-9, 10, 11, 12-tetrahydro-7H-benzo [7, 8] …