[HTML][HTML] Pharmacological cardioprotection against ischemia reperfusion injury—the search for a clinical effective therapy
Q Wang, CJ Zuurbier, R Huhn, C Torregroza… - Cells, 2023 - mdpi.com
Pharmacological conditioning aims to protect the heart from myocardial ischemia-
reperfusion injury (IRI). Despite extensive research in this area, today, a significant gap …
reperfusion injury (IRI). Despite extensive research in this area, today, a significant gap …
Medicinal chemistry strategies targeting NLRP3 inflammasome pathway: A recent update from 2019 to mid-2023
M Duan, L Sun, X He, Z Wang, Y Hou, Y Zhao - European Journal of …, 2023 - Elsevier
Nod-like receptor protein 3 (NLRP3), a therapeutic target that has a close relationship with
inflammatory diseases, has drawn significant attention from researchers in the field. An …
inflammatory diseases, has drawn significant attention from researchers in the field. An …
[HTML][HTML] Initial Despair and Current Hope of Identifying a Clinically Useful Treatment of Myocardial Reperfusion Injury: Insights Derived from Studies of Platelet P2Y12 …
MV Cohen, JM Downey - International Journal of Molecular Sciences, 2024 - mdpi.com
Myocardial necrosis following the successful reperfusion of a coronary artery occluded by
thrombus in a patient presenting with ST-elevation myocardial infarction (STEMI) continues …
thrombus in a patient presenting with ST-elevation myocardial infarction (STEMI) continues …
The research progression of direct NLRP3 inhibitors to treat inflammatory disorders
X Chen, P Zhang, Y Zhang, M Wei, T Tian, D Zhu… - Cellular …, 2024 - Elsevier
The NLRP3 inflammasome represents a cytoplasmic multiprotein complex with the
capability to recognize a wide range of pathogen-derived, environmental, and endogenous …
capability to recognize a wide range of pathogen-derived, environmental, and endogenous …
[HTML][HTML] Bone-marrow mononuclear cells and acellular human amniotic membrane improve global cardiac function without inhibition of the NLRP3 Inflammasome in a …
AL Takejima, PAB Machado-Júnior… - Anais da Academia …, 2024 - SciELO Brasil
Recent studies have suggested that therapies with stem cells and amniotic membrane can
modulate the inflammation following an ischemic injury in the heart. This study evaluated the …
modulate the inflammation following an ischemic injury in the heart. This study evaluated the …