[HTML][HTML] Mechanistic insights and perspectives involved in neuroprotective action of quercetin

AK Grewal, TG Singh, D Sharma, V Sharma… - Biomedicine & …, 2021 - Elsevier
Neurodegenerative diseases (NDDs) are the primary cause of disabilities in the elderly
people. Growing evidence indicates that oxidative stress, mitochondrial dysfunction …

Apoptotic pathways and Alzheimer's disease: probing therapeutic potential

VK Sharma, TG Singh, S Singh, N Garg… - Neurochemical …, 2021 - Springer
Apoptosis is an intrinsic biochemical, cellular process that regulates cell death and is crucial
for cell survival, cellular homeostasis, and maintaining the optimum functional status …

Histone modifications in Alzheimer's disease

DA Santana, MAC Smith, ES Chen - Genes, 2023 - mdpi.com
Since Late-onset Alzheimer's disease (LOAD) derives from a combination of genetic variants
and environmental factors, epigenetic modifications have been predicted to play a role in the …

Dysbiosis and Alzheimer's disease: a role for chronic stress?

VK Sharma, TG Singh, N Garg, S Dhiman, S Gupta… - Biomolecules, 2021 - mdpi.com
Alzheimer's disease (AD) is an incurable, neuropsychiatric, pathological condition that
deteriorates the worth of geriatric lives. AD is characterized by aggregated senile amyloid …

[HTML][HTML] Role of primary aging hallmarks in Alzheimer´ s disease

J Zhao, J Huai - Theranostics, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

Calpain inhibitors as potential therapeutic modulators in neurodegenerative diseases

H Khan, N Garg, TG Singh, A Kaur, K Thapa - Neurochemical Research, 2022 - Springer
It is considered a significant challenge to understand the neuronal cell death mechanisms
with a suitable cure for neurodegenerative disorders in the coming years. Calpains are one …

Neuroepigenetics of ageing and neurodegeneration-associated dementia: an updated review

FA Mir, A Amanullah, BP Jain, Z Hyderi… - Ageing Research …, 2023 - Elsevier
Gene expression is tremendously altered in the brain during memory acquisition, recall, and
forgetfulness. However, non-genetic factors, including environmental elements, epigenetic …

CREB: a multifaceted target for Alzheimer's disease

VK Sharma, TG Singh - Current Alzheimer Research, 2020 - ingentaconnect.com
Alzheimer's disease (AD) is a persistent neuropathological stipulation manifested in the form
of neuronal/synapse demise, the formation of senile plaques, hyperphosphorylated tau …

Gut microbiota composition and epigenetic molecular changes connected to the pathogenesis of Alzheimer's disease

P Nagu, A Parashar, T Behl, V Mehta - Journal of Molecular Neuroscience, 2021 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder, and its pathogenesis is not fully
known. Although there are several hypotheses, such as neuroinflammation, tau …

Stressed mitochondria: A target to intrude Alzheimer's disease

VK Sharma, TG Singh, V Mehta - Mitochondrion, 2021 - Elsevier
Alzheimer's disease (AD) is the inoperable, incapacitating, neuropsychiatric, and
degenerative manifestation that drastically affects human life quality. The current …