Highlights•Solid organ transplantation (SOT) patients or patients with active ADs have been
largely excluded from ICIs clinical trials because of the risk of allograft rejection or severe …

Background Biologics are used for the treatment of rheumatoid arthritis and many other
conditions. While the efficacy of biologics has been established, there is uncertainty …

Ankylosing spondylitis is a common inflammatory rheumatic disease that affects the axial
skeleton, causing characteristic inflammatory back pain, which can lead to structural and …

Objective To evaluate the safety and efficacy of adalimumab, a fully human recombinant
IgG1 monoclonal antibody that specifically targets human tumor necrosis factor, in patients …

Objective: To develop evidence based recommendations for the management of ankylosing
spondylitis (AS) as a combined effort of the 'ASsessment in AS'international working group …

Objectives This meta-analysis investigates the efficacy of tumour necrosis factor α (TNFα)
blockers versus placebo for the treatment of ankylosing spondylitis (AS) and non …

Background TNF (tumor necrosis factor)‐alpha inhibitors block a key protein in the
inflammatory chain reaction responsible for joint inflammation, pain, and damage in …

Rationale: An efficacious medical therapy for idiopathic pulmonary fibrosis (IPF) remains
elusive. Objectives: To explore the efficacy and safety of etanercept in the treatment of IPF …

Rationale: Depression and anxiety are significant comorbid and potentially modifiable
conditions in chronic obstructive pulmonary disease (COPD), but their effects on …

Results from clinical trials of biologic anti-TNF drugs performed in the late 1990s confirmed
the biological relevance of TNF function in the pathogenesis of chronic noninfectious …