DNA replication is a highly demanding process regarding the energy and material supply
and must be precisely regulated, involving multiple cellular feedbacks. The slowing down or …

Hydroxyurea (HU) is a water‐soluble antiproliferative agent used for decades in neoplastic
and nonneoplastic conditions. HU is considered an essential medicine because of its …

Biologic and clinical observations suggest that combining imatinib with IFN-α may improve
treatment outcome in chronic myeloid leukemia (CML). We randomized newly diagnosed …

The 17th meeting of the WHO Expert Committee on the Selection and Use of Essential
Medicines was held in Geneva from 23rd to 27th March 2009. The meeting was opened on …

Treatment options for chronic myeloid leukemia (CML) have changed dramatically during
the last decades. Interferon-α treatment and stem cell transplantation (SCT) clearly improved …

Previous studies have shown that exposure of cells to high levels of replicational stress
leads to permanent proliferation arrest that does not require p53. We have examined cellular …

Merkel cell carcinoma (MCC) is a rare and highly aggressive skin cancer associated with the
Merkel cell polyomavirus (MCV). As MCC cell lines show oncogene addiction to the MCV T …

Chronic myeloid leukemia is a myeloproliferative neoplasm that occurs more prominently in
the older population, with a peak incidence at ages 45 to 85 years and a median age at …

Treatment of chronic myeloid leukemia (CML) with interferon-alpha (IFN-α) was introduced
in the early 1980s. Several clinical trials showed a survival advantage for patients treated …

Introduction. The survival of patients with chronic myelocytic leukemia (CML) has improved
during the past decades. However, there have been discrepancies between results reported …