Malaria is a leading cause of mortality and morbidity globally, and effective vaccines are
urgently needed. Malaria vaccine approaches can be broadly grouped as pre‐erythrocytic …

For many pathogens the availability of genome sequence, permitting genome-dependent
methods of research, can partially substitute for powerful forward genetic methods (genome …

Abstract Background The apicomplexan parasite Plasmodium falciparum causes the most
severe form of malaria in humans. After invasion into erythrocytes, asexual parasite stages …

Genetic variation allows the malaria parasite Plasmodium falciparum to overcome
chemotherapeutic agents, vaccines and vector control strategies and remain a leading …

Malaria parasites (Plasmodium falciparum) provide an excellent system in which to study the
genomic effects of strong selection in a recombining eukaryote because the rapid spread of …

Background Accurate diagnosis is essential for prompt and appropriate treatment of malaria.
While rapid diagnostic tests (RDTs) offer great potential to improve malaria diagnosis, the …

A central challenge of genomics is to detect, simply and inexpensively, all differences in
sequence among the genomes of individual members of a species. We devised a system to …

Understanding the influences of population structure, selection, and recombination on
polymorphism and linkage disequilibrium (LD) is integral to mapping genes contributing to …

One goal in sequencing the Plasmodium falciparum genome, the agent of the most lethal
form of malaria, is to discover vaccine and drug targets. However, identifying those targets in …

Discovering novel genes involved in immune evasion and drug resistance in the human
malaria parasite, Plasmodium falciparum, is of critical importance to global health. Such …