Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

A concurrent cascade combining the use of a gold (I) N-heterocyclic carbene (NHC) and an
alcohol dehydrogenase (ADH) is disclosed for the synthesis of highly valuable enantiopure …

Biocatalysis has emerged as a promising alternative to conventional chemical processes for
the production of a wide range of chemicals, providing a sustainable solution to the problem …

The synthesis of enantioenriched β-chlorohydrins is highly appealing due to their relevance
as building-blocks in organic synthesis. However, the approximation to aliphatic derivatives …

Encapsulating enzymes within metal–organic frameworks such as zeolitic imidazolate
framework-8 (ZIF-8) has been demonstrated to enhance enzymatic performance under …

The serine 244 to aspartate (S244D) variant of the cytochrome P450 enzyme CYP199A4
was used to expand its substrate range beyond benzoic acids. Substrates, in which the …

Biocatalysis in organic solvents (OSs) has numerous important applications, but native
enzymes in OSs often exhibit limited catalytic performance. Herein, we proposed a …

Applications of haloalkane dehalogenase DhaA in biocatalysis are limited by its unfavorable
performance in organic solvents. Our previous work proved that mutations of surface positive …

Vicinal halohydrins are key building blocks to produce bioactive molecules and drugs,
especially if they can be obtained in enantiomerically pure form. In this study, we present a …

En esta Tesis Doctoral se aborda la combinación de dos metodologías catalíticas como son
el empleo de enzimas y especies metálicas como aceleradores de reacciones químicas …