[HTML][HTML] Emerging concepts in the science of vaccine adjuvants
B Pulendran, P S. Arunachalam… - Nature Reviews Drug …, 2021 - nature.com
Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …
the immune response. Following its introduction in the 1920s, alum remained the only …
[HTML][HTML] Human immune diversity: from evolution to modernity
The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
[HTML][HTML] Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial
Patients with rheumatoid arthritis (RA) receive highly targeted biologic therapies without
previous knowledge of target expression levels in the diseased tissue. Approximately 40 …
previous knowledge of target expression levels in the diseased tissue. Approximately 40 …
[HTML][HTML] Systems vaccinology of the BNT162b2 mRNA vaccine in humans
The emergency use authorization of two mRNA vaccines in less than a year from the
emergence of SARS-CoV-2 represents a landmark in vaccinology,. Yet, how mRNA …
emergence of SARS-CoV-2 represents a landmark in vaccinology,. Yet, how mRNA …
[HTML][HTML] Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly
infectious respiratory virus which is responsible for the coronavirus disease 2019 (COVID …
infectious respiratory virus which is responsible for the coronavirus disease 2019 (COVID …
[HTML][HTML] Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans
Nutrition has broad impacts on all physiological processes. However, how nutrition affects
human immunity remains largely unknown. Here we explored the impact of a dietary …
human immunity remains largely unknown. Here we explored the impact of a dietary …
Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans
Coronavirus disease 2019 (COVID-19) represents a global crisis, yet major knowledge gaps
remain about human immunity to severe acute respiratory syndrome coronavirus 2 (SARS …
remain about human immunity to severe acute respiratory syndrome coronavirus 2 (SARS …
[HTML][HTML] Bifidobacteria-mediated immune system imprinting early in life
Immune-microbe interactions early in life influence the risk of allergies, asthma, and other
inflammatory diseases. Breastfeeding guides healthier immune-microbe relationships by …
inflammatory diseases. Breastfeeding guides healthier immune-microbe relationships by …
[HTML][HTML] Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients
Z Sun, ZG Song, C Liu, S Tan, S Lin, J Zhu, FH Dai… - BMC medicine, 2022 - Springer
Background COVID-19 is an infectious disease characterized by multiple respiratory and
extrapulmonary manifestations, including gastrointestinal symptoms. Although recent …
extrapulmonary manifestations, including gastrointestinal symptoms. Although recent …
[HTML][HTML] Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination
Several studies have shown that the pre-vaccination immune state is associated with the
antibody response to vaccination. However, the generalizability and mechanisms that …
antibody response to vaccination. However, the generalizability and mechanisms that …