Abstract Potassium channels (K+-channels) selectively control the passive flow of potassium
ions across biological membranes and thereby also regulate membrane excitability. Genetic …

KCNQ2-related disorders represent a continuum of overlapping neonatal epileptic
phenotypes ranging from self-limited familial neonatal epilepsy (SLFNE) at the mild end to …

Toxicogenomics is a critical area of inquiry for hazard identification and to identify both
mechanisms of action and potential markers of exposure to toxic compounds. However, data …

Loss-and gain-of-function variants in the gene encoding KCNQ2 channels are a common
cause of developmental and epileptic encephalopathy, a condition characterized by …

Background De novo missense variants in KCNQ5, encoding the voltage-gated K+ channel
KV 7.5, have been described to cause developmental and epileptic encephalopathy (DEE) …

Abstract Background and Purpose Excitotoxicity due to mitochondrial calcium (Ca2+)
overloading can trigger neuronal cell death in a variety of pathologies. Inhibiting the …

KCNQ5 encodes the voltage-gated potassium channel KV 7.5, a member of the KV 7
channel family, which conducts the M-current. This current is a potent regulator of neuronal …

Heightened excitability of vagal sensory neurons in inflammatory visceral diseases
contributes to unproductive and difficult-to-treat neuronally based symptoms such as visceral …

Dominant KCNQ1 variants are well-known for underlying cardiac arrhythmia syndromes.
The two heterozygous KCNQ1 missense variants, R116L and P369L, cause an allelic …

Potassium (K+) channels are the largest group of ion channels in mammals. The immediate
function of these channels is electrogenic transport of K+ ions across the cellular …