The epidermal growth factor receptor (EGFR) family contains four transmembrane tyrosine
kinases (EGFR1/ErbB1, Her2/ErbB2, Her3/ErbB3 and Her4/ErbB4) and 13 secreted …

Introduction: Cancer is a devastating disease; however, several therapeutic advances have
recently been made, wherein EGFR and its family members have emerged as useful …

Currently, the humanity is in a fierce battle against various health-related challenges
especially those associated with human malignancies. This created the urge to develop …

Protein kinases have grown over the past few years as a crucial target for different cancer
types. With the multifactorial nature of cancer, and the fast development of drug resistance …

Ovarian cancer has become the largest cause of gynaecological cancer-related mortality. It
is typically diagnosed at a late stage and has no effective screening strategy. Ovarian cancer …

Cancer therapies targeting epidermal growth factor receptor (EGFR), such as small-
molecule kinase inhibitors and monoclonal antibodies, have been developed as standard …

Context: Genetic alterations in receptor tyrosine kinases (RTKs) and phosphatidylinositol 3-
kinase (PI3K)/Akt and MAPK pathways have not been fully defined in anaplastic and …

Tumor hypoxia is a common feature of the tumor microenvironment and has been regarded
as one of the key factors in driving the emergence of drug resistance in solid tumors. To …

The Warburg effect is a phenomenon in which cancer cells rely primarily on glycolysis rather
than oxidative phosphorylation, even in the presence of oxygen. Although evidence of its …

Introduction Non-small cell lung cancer (NSCLC) frequently presents at an incurable stage,
and a majority of patients will be considered for palliative chemotherapy at some point in …