Collagen-and hyaluronic acid-based hydrogels and their biomedical applications

Q Xu, JE Torres, M Hakim, PM Babiak, P Pal… - Materials Science and …, 2021 - Elsevier
Hydrogels have been widely investigated in biomedical fields due to their similar physical
and biochemical properties to the extracellular matrix (ECM). Collagen and hyaluronic acid …

[HTML][HTML] From structure to phenotype: impact of collagen alterations on human health

L Arseni, A Lombardi, D Orioli - International journal of molecular sciences, 2018 - mdpi.com
The extracellular matrix (ECM) is a highly dynamic and heterogeneous structure that plays
multiple roles in living organisms. Its integrity and homeostasis are crucial for normal tissue …

The triple helix of collagens–an ancient protein structure that enabled animal multicellularity and tissue evolution

AL Fidler, SP Boudko, A Rokas… - Journal of cell …, 2018 - journals.biologists.com
The cellular microenvironment, characterized by an extracellular matrix (ECM), played an
essential role in the transition from unicellularity to multicellularity in animals (metazoans) …

Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families

N Akawi, J McRae, M Ansari, M Balasubramanian… - Nature …, 2015 - nature.com
Discovery of most autosomal recessive disease-associated genes has involved analysis of
large, often consanguineous multiplex families or small cohorts of unrelated individuals with …

Early onset hereditary neuronopathies: an update on non-5q motor neuron diseases

AA Zambon, V Pini, L Bosco, YM Falzone, P Munot… - Brain, 2023 - academic.oup.com
Hereditary motor neuropathies (HMN) were first defined as a group of neuromuscular
disorders characterized by lower motor neuron dysfunction, slowly progressive length …

Ocular ptosis: differential diagnosis and treatment

J Díaz-Manera, S Luna, C Roig - Current opinion in neurology, 2018 - journals.lww.com
We emphasize that ptosis should be studied as a complex symptom. Efforts should be made
to identify accompanying neurologic or ophthalmologic signs in clinical examination that …

Exploring the roles of MACIT and multiplexin collagens in stem cells and cancer

V Izzi, R Heljasvaara, A Heikkinen… - Seminars in Cancer …, 2020 - Elsevier
The extracellular matrix (ECM) is ubiquitously involved in neoplastic transformation, tumour
growth and metastatic dissemination, and the interplay between tumour and stromal cells …

Collagen XIII and other ECM components in the assembly and disease of the neuromuscular junction

A Heikkinen, H Härönen, O Norman… - The Anatomical …, 2020 - Wiley Online Library
Alongside playing structural roles, the extracellular matrix (ECM) acts as an interaction
platform for cellular homeostasis, organ development, and maintenance. The necessity of …

A local regulatory network in the testis mediated by laminin and collagen fragments that supports spermatogenesis

L Li, H Li, L Wang, T Bu, S Liu, B Mao… - Critical Reviews in …, 2021 - Taylor & Francis
It is almost five decades since the discovery of the hypothalamic-pituitary-testicular axis. This
refers to the hormonal axis that connects the hypothalamus, pituitary gland and testes, which …

[HTML][HTML] Roles of collagen XXV and its putative receptors PTPσ/δ in intramuscular motor innervation and congenital cranial dysinnervation disorder

H Munezane, H Oizumi, T Wakabayashi, S Nishio… - Cell Reports, 2019 - cell.com
Intramuscular motor innervation is an essential process in neuromuscular development.
Recently, mutations in COL25A1, encoding CLAC-P/collagen XXV, have been linked to the …