Although much maligned, the amyloid-β (Aβ) protein has been shown to possess a number
of trophic properties that emanate from the protein's ability to bind Cu, Fe and Zn. Aβ …

Abstract Neurodegeneration in Parkinson's, Alzheimer's, or other neurodegenerative
diseases appears to be multifactorial, where a complex set of toxic reactions, including …

It is discussed that Alzheimer disease does not form a nosologic entity. 5 to 10% of all
Alzheimer cases are due to inherited abnormalities on chromosomes 1, or 14, or 21 …

Nosologically, Alzheimer disease may not be considered to be a single disorder in spite of a
common clinical phenotype. Only a small proportion of about 5% to 10% of all Alzheimer …

Although iron is essential in maintaining the function of the central nervous system, it is a
potent source of reactive oxygen species. Excessive iron accumulation occurs in many …

The use of human brain tissue obtained at autopsy for neurochemical, pharmacological and
physiological analyses is reviewed. RNA and protein samples have been found suitable for …

Research into Alzheimer's disease (AD) has been guided by the view that deposits of fibrillar
amyloid-β peptide (Aβ) are neurotoxic and are largely responsible for the …

For nearly 20 years, the primary focus for researchers studying Alzheimer disease has been
centered on amyloid-β, such that the amyloid cascade hypothesis has become the “null …

Silent stroke is one of the risk factors of dementia. In the present study, we used a novel focal
ischemic animal model to investigate the effects of comparatively small changes of cerebral …

The anti‐Parkinson drug, rasagiline (N‐propargyl‐(1R)‐aminoindan) promotes neuronal
survival, via neuroprotective activity related to its propargyl moiety (propargylamine). We …