Antimalarial drugs are key tools for the control and elimination of malaria. Recent decreases
in the global malaria burden are likely due, in part, to the deployment of artemisinin-based …

Malaria is a great concern for global health and accounts for a large amount of morbidity and
mortality, particularly in Africa, with sub-Saharan Africa carrying the greatest burden of the …

Ethiopia is one of the few African countries where Plasmodium vivax is co-endemic with P.
falciparum. Malaria transmission is seasonal and transmission intensity varies mainly by …

Background The present paper reports on studies that evaluated artesunate+ sulfadoxine-
pyrimethamine (AS+ SP) which is the first-line drug and artemether-lumefantrine (AL) which …

Faced with intense levels of chloroquine (CQ) resistance in Plasmodium falciparum malaria,
Rwanda replaced CQ with amodiaquine (AQ)+ sulfadoxine-pyrimethamine (SP) in 2001 …

Background: We prepared a novel series of enantiopure mefloquine analogues with pyrrolo
[1, 2-a] quinoxaline core in order to fight Plasmodium falciparum resistant strain. Objectives …

In traditional Chinese medicine, Ranunculus japonicus has been used to treat various
diseases, including malaria, and the young stem of R. japonicus is consumed as a food in …

Background The emergence of parasite drug resistance, especially Plasmodium falciparum,
persists as a major obstacle for malaria control and elimination. To develop effective public …

Antimalarial drug resistance is one of the major challenges in global efforts of malaria
control and elimination. In 1998, chloroquine was abandoned and replaced with …

Drug resistance is an important problem hindering malaria elimination in tropical areas.
Point mutations in Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and …