The small mammalian mitochondrial DNA (mtDNA) is very gene dense and encodes factors
critical for oxidative phosphorylation. Mutations of mtDNA cause a variety of human …

A large group of mitochondrial disorders, ranging from early-onset pediatric
encephalopathic syndromes to late-onset myopathy with chronic progressive external …

In response to stress, p53 initiates the transcriptional regulation of selected target genes and
various cellular responses, including cell cycle arrest, apoptosis and senescence. Recent …

Disruption of the most fundamental cellular energy process, the mitochondrial respiratory
chain, results in a diverse and variable group of multisystem disorders known collectively as …

Mitochondrial diseases (encephalomyopathies) have traditionally been ascribed to defects
of the respiratory chain, which has helped researchers explain their genetic and clinical …

Current drug development in oncology is non-selective as it typically focuses on pathways
essential for the survival of all dividing cells. The unique metabolic profile of cancer, which is …

Resveratrol (3, 5, 4′-trihydroxy-trans-stilbene; RV), a dietary constituent found in grapes
and wine, exerts a wide variety of pharmacological activities. Because the grape skins are …

We are increasingly aware that cellular metabolism plays a vital role in diseases such as
cancer, and that p53 is an important regulator of metabolic pathways. By transcriptional …

Cancer was recognized as a genetic disease at least four decades ago, with the realization
that the spontaneous mutation rate must increase early in tumorigenesis to account for the …

Significance: The p53 tumor suppressor has been dubbed the “guardian of genome”
because of its various roles in the response to DNA damage such as DNA damage repair …