Systemic lupus erythematosus pathogenesis: interferon and beyond
Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …
[HTML][HTML] The human antibody response to influenza A virus infection and vaccination
F Krammer - Nature Reviews Immunology, 2019 - nature.com
The adaptive immune response to influenza virus infection is multifaceted and complex,
involving antibody and cellular responses at both systemic and mucosal levels. Immune …
involving antibody and cellular responses at both systemic and mucosal levels. Immune …
Immune responses to two and three doses of the BNT162b2 mRNA vaccine in adults with solid tumors
RT Shroff, P Chalasani, R Wei, D Pennington… - Nature medicine, 2021 - nature.com
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have
shown high efficacy, but immunocompromised participants were excluded from controlled …
shown high efficacy, but immunocompromised participants were excluded from controlled …
Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19
The durability of infection-induced SARS-CoV-2 immunity has major implications for
reinfection and vaccine development. Here, we show a comprehensive profile of antibody, B …
reinfection and vaccine development. Here, we show a comprehensive profile of antibody, B …
Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
dramatically expedited global vaccine development efforts,–, most targeting the viral …
dramatically expedited global vaccine development efforts,–, most targeting the viral …
Comprehensive mapping of immune perturbations associated with severe COVID-19
L Kuri-Cervantes, MB Pampena, W Meng… - Science …, 2020 - science.org
Although critical illness has been associated with SARS-CoV-2–induced hyperinflammation,
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …
Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine
We examined antibody and memory B cell responses longitudinally for∼ 9–10 months after
primary 2-dose SARS-CoV-2 mRNA vaccination and 3 months after a 3rd dose. Antibody …
primary 2-dose SARS-CoV-2 mRNA vaccination and 3 months after a 3rd dose. Antibody …
Challenges and opportunities for consistent classification of human B cell and plasma cell populations
I Sanz, C Wei, SA Jenks, KS Cashman… - Frontiers in …, 2019 - frontiersin.org
The increasingly recognized role of different types of B cells and plasma cells in protective
and pathogenic immune responses combined with technological advances have generated …
and pathogenic immune responses combined with technological advances have generated …
Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics
Protective humoral memory forms in secondary lymphoid organs where B cells undergo
affinity maturation and differentiation into memory or plasma cells. Here, we provide a …
affinity maturation and differentiation into memory or plasma cells. Here, we provide a …
Distinct effector B cells induced by unregulated toll-like receptor 7 contribute to pathogenic responses in systemic lupus erythematosus
SA Jenks, KS Cashman, E Zumaquero, UM Marigorta… - Immunity, 2018 - cell.com
Summary Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …