The importance and role of the estrogen receptor (ER) pathway has been well-documented
in both breast cancer (BC) development and progression. The treatment of choice in women …

The secretion of glucocorticoids (GCs) is a classic endocrine response to stress. Despite
that, it remains controversial as to what purpose GCs serve at such times. One view …

Alterations in estrogen-mediated cellular signaling play an essential role in the
pathogenesis of endometriosis. In addition to higher estrogen receptor (ER) β levels …

The actions of androgens such as testosterone and dihydrotestosterone are mediated via
the androgen receptor (AR), a ligand-dependent nuclear transcription factor and member of …

The induction of expression of genes for xenobiotic metabolizing enzymes in response to
chemical insult is an adaptive response found in most organisms. In vertebrates, the AhR is …

Our appreciation of the physiological functions of estrogens and the mechanisms through
which estrogens bring about these functions has changed during the past decade. Just as …

Elwood Jensen and Jack Gorski had spent 10 yr providing experimental evidence to support
the concept of an intracellular “receptor” protein for steroid hormones. Their combined work …

The estrogen receptor (ER) is a ligand-activated enhancer protein that is a member of the
steroid/nuclear receptor superfamily. Two genes encode mammalian ER: ERα and ERβ. ER …

Nuclear receptor pharmacology has, to a certain extent, led the way, compared with other
receptor systems, in the appreciation that ligands may exert very diverse pharmacology …

17β-Estradiol (E2) controls many aspects of human physiology, including development,
reproduction and homeostasis, through regulation of the transcriptional activity of its cognate …