Sialic acids in human health and disease

A Varki - Trends in molecular medicine, 2008 - cell.com
The surfaces of all vertebrate cells are decorated with a dense and complex array of sugar
chains, which are mostly attached to proteins and lipids. Most soluble secreted proteins are …

Oligosaccharide specificity of galectins: a search by frontal affinity chromatography

J Hirabayashi, T Hashidate, Y Arata, N Nishi… - … et Biophysica Acta (BBA …, 2002 - Elsevier
Galectins are widely distributed sugar-binding proteins whose basic specificity for β-
galactosides is conserved by evolutionarily preserved carbohydrate-recognition domains …

[HTML][HTML] Applications of nanobiomaterials in the therapy and imaging of acute liver failure

Y Jin, H Wang, K Yi, S Lv, H Hu, M Li, Y Tao - Nano-micro letters, 2021 - Springer
Highlights This review focuses on the therapeutic mechanisms, targeting strategies of
various nanomaterials in acute liver failure, and recent advances of diverse nanomaterials …

From lectin structure to functional glycomics: principles of the sugar code

HJ Gabius, S André, J Jiménez-Barbero… - Trends in biochemical …, 2011 - cell.com
Lectins are carbohydrate-binding proteins which lack enzymatic activity on their ligand and
are distinct from antibodies and free mono-and oligosaccharide sensor/transport proteins …

Glycosylation of therapeutic proteins: an effective strategy to optimize efficacy

RJ Solá, K Griebenow - BioDrugs, 2010 - Springer
During their development and administration, protein-based drugs routinely display
suboptimal therapeutic efficacies due to their poor physicochemical and pharmacological …

Pectin in cancer therapy: A review

W Zhang, P Xu, H Zhang - Trends in Food Science & Technology, 2015 - Elsevier
Highlights•Overview of the application and anti-cancer mechanisms of dietary
pectin.•Structure-activity relationships of modified pectin are discussed.•Anti-cancer …

The mannose receptor family

L East, CM Isacke - Biochimica et Biophysica Acta (BBA)-General Subjects, 2002 - Elsevier
The mannose receptor family comprises four glycoproteins each of which is a type I
transmembrane receptor with an N-terminal cysteine-rich domain, a single fibronectin type II …

Chondroitin sulphate: a focus on osteoarthritis

M Bishnoi, A Jain, P Hurkat, SK Jain - Glycoconjugate journal, 2016 - Springer
Chondroitin sulfate (CS) being a natural glycosaminoglycan is found in the cartilage and
extracellular matrix. It shows clinical benefits in symptomatic osteoarthritis (OA) of the finger …

Prodrug strategies in anticancer chemotherapy

F Kratz, IA Müller, C Ryppa… - … Chemistry Enabling Drug …, 2008 - Wiley Online Library
The majority of clinically approved anticancer drugs are characterized by a narrow
therapeutic window that results mainly from a high systemic toxicity of the drugs in …

Chemical biology of the sugar code

HJ Gabius, HC Siebert, S André… - …, 2004 - Wiley Online Library
A high‐density coding system is essential to allow cells to communicate efficiently and
swiftly through complex surface interactions. All the structural requirements for forming a …