Roles of transposable elements in the regulation of mammalian transcription

R Fueyo, J Judd, C Feschotte, J Wysocka - Nature reviews Molecular …, 2022 - nature.com
Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …

Cis-regulatory sequences in plants: their importance, discovery, and future challenges

RJ Schmitz, E Grotewold, M Stam - The plant cell, 2022 - academic.oup.com
The identification and characterization of cis-regulatory DNA sequences and how they
function to coordinate responses to developmental and environmental cues is of paramount …

Origins and evolutionary consequences of ancient endogenous retroviruses

WE Johnson - Nature Reviews Microbiology, 2019 - nature.com
Retroviruses infect a broad range of vertebrate hosts that includes amphibians, reptiles, fish,
birds and mammals. In addition, a typical vertebrate genome contains thousands of loci …

Mammalian genome innovation through transposon domestication

AJ Modzelewski, J Gan Chong, T Wang, L He - Nature cell biology, 2022 - nature.com
Since the discovery of transposons, their sheer abundance in host genomes has puzzled
many. While historically viewed as largely harmless 'parasitic'DNAs during evolution …

Transposable elements as essential elements in the control of gene expression

A Gebrie - Mobile DNA, 2023 - Springer
Interspersed repetitions called transposable elements (TEs), commonly referred to as mobile
elements, make up a significant portion of the genomes of higher animals. TEs contribute in …

Transposable elements as a potent source of diverse cis-regulatory sequences in mammalian genomes

V Sundaram, J Wysocka - Philosophical Transactions of …, 2020 - royalsocietypublishing.org
Eukaryotic gene regulation is mediated by cis-regulatory elements, which are embedded
within the vast non-coding genomic space and recognized by the transcription factors in a …

The epigenomic landscape of transposable elements across normal human development and anatomy

EC Pehrsson, MNK Choudhary, V Sundaram… - Nature …, 2019 - nature.com
Transposable elements (TEs) have deposited functional regulatory elements throughout the
human genome. Although most are silenced, certain TEs have been co-opted by the host …

[HTML][HTML] Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells

J He, X Fu, M Zhang, F He, W Li, MM Abdul… - Nature …, 2019 - nature.com
The majority of mammalian genomes are devoted to transposable elements (TEs). Whilst
TEs are increasingly recognized for their important biological functions, they are a potential …

Evolutionary rewiring of the wheat transcriptional regulatory network by lineage-specific transposable elements

Y Zhang, Z Li, K Lin, Y Peng, L Ye, Y Zhuang… - Genome …, 2021 - genome.cshlp.org
More than 80% of the wheat genome consists of transposable elements (TEs), which act as
major drivers of wheat genome evolution. However, their contributions to the regulatory …

[HTML][HTML] The placenta goes viral: Retroviruses control gene expression in pregnancy

EB Chuong - PLoS biology, 2018 - journals.plos.org
The co-option of endogenous retroviruses (ERVs) is increasingly recognized as a recurrent
theme in placental biology, which has far-reaching implications for our understanding of …