G protein-coupled receptors (GPCRs) are involved in numerous key neurotransmitter
systems in the brain that are disrupted in Alzheimer's disease (AD). GPCRs also directly …

Now there is general agreement that the purine nucleoside adenosine is an important
neuromodulator in the central nervous system, playing a crucial role in neuronal excitability …

The effects of caffeine on extracellular dopamine and acetylcholine have been studied in
freely moving rats implanted with concentric microdialysis probes in the nucleus accumbens …

Alzheimer's disease (AD) is a neurodegenerative disorder of the central nervous system
manifested by cognitive and memory deterioration, a variety of neuropsychiatric symptoms …

The hippocampal GABAergic system is assumed not to be a target for purine modulation.
We have now confirmed that neither adenosine A1 and A3 receptor nor nucleotide P2 or P4 …

Adenosine's effects result from a balanced activation of inhibitory A1 and facilitatory A2A
receptors. Because in aged animals there is an increased number of A2A receptors, we now …

The activation of adenosine Al, A2 and A3 receptors can protect neurones against damage
generated by mechanical or hypoxic/ischaemic insults as well as excitotoxins. Al receptors …

Although molecular biology studies indicate the presence of adenosine A2A receptors in the
rat hippocampus, the pharmacological characterization of adenosine A2A receptor binding …

Rat striatal and hippocampal slices, preincubated with [3 H] dopamine (DA){or [3 H]
noradrenaline (NA)} and [14 C] choline, were superfused continuously and stimulated …

Background Adenosine modulates cell excitability, acetylcholine release, nociception, and
sleep. Pontine cholinergic neurotransmission contributes to the generation and …