Natural and synthetic saponins as vaccine adjuvants

P Wang - Vaccines, 2021 - mdpi.com
Saponin adjuvants have been extensively studied for their use in veterinary and human
vaccines. Among them, QS-21 stands out owing to its unique profile of immunostimulating …

Plasmodium falciparum Malaria Vaccines and Vaccine Adjuvants

SR Bonam, L Rénia, G Tadepalli, J Bayry, HMS Kumar - Vaccines, 2021 - mdpi.com
Malaria—a parasite vector-borne disease—is a global health problem, and Plasmodium
falciparum has proven to be the deadliest among Plasmodium spp., which causes malaria in …

Conjugation of mannans to enhance the potency of liposome nanoparticles for the delivery of RNA vaccines

R Goswami, DT O'Hagan, R Adamo, BC Baudner - Pharmaceutics, 2021 - mdpi.com
Recent approval of mRNA vaccines to combat COVID-19 have highlighted the potential of
this platform. Lipid nanoparticles (LNP) is the delivery vehicle of choice for mRNA as they …

Purification, Structural Characterization and Immunomodulatory Effects of Polysaccharides from Amomum villosum Lour. on RAW 264.7 Macrophages

Y Zhou, C Qian, D Yang, C Tang, X Xu, EH Liu… - Molecules, 2021 - mdpi.com
Amomum Villosum Lour.(A. villosum) is a folk medicine that has been used for more than
1300 years. However, study of the polysaccharides of A. villosum is seriously neglected. The …

Synthesis and biological evaluation of novel 4, 7-disubstituted coumarins as selective tumor-associated carbonic anhydrase IX and XII inhibitors

KM Chandra, NS Goud, M Arifuddin, M Alvala… - Bioorganic & Medicinal …, 2021 - Elsevier
With an aim to develop novel potential anti-cancer agents we have designed a series of
novel 4, 7-disubstituted coumarin hybrids synthesis and evaluated for their inhibitory activity …

The search of a malaria vaccine: the time for modified immuno-potentiating probes

JM Lozano, Z Rodríguez Parra, S Hernández-Martínez… - Vaccines, 2021 - mdpi.com
Malaria is a deadly disease that takes the lives of more than 420,000 people a year and is
responsible for more than 229 million clinical cases globally. In 2019, 95% of malaria …

The effect of a TLR4 agonist/cationic liposome adjuvant on varicella-zoster virus glycoprotein E vaccine efficacy: antigen presentation, uptake, and delivery to lymph …

SR Wui, A Ko, JI Ryu, E Sim, SJ Lim, SA Park, KS Kim… - Pharmaceutics, 2021 - mdpi.com
Adjuvant CIA09, composed of 1, 2-dioleoyl-3-trimethylammonium-propane (DOTAP)-based
cationic liposomes and the toll-like receptor 4 agonist de-O-acylated lipooligosaccharide …

Cyclic di-adenosine monophosphate: a promising adjuvant candidate for the development of neonatal vaccines

D Lirussi, SF Weissmann, T Ebensen, U Nitsche-Gloy… - Pharmaceutics, 2021 - mdpi.com
Underdeveloped immunity during the neonatal age makes this period one of the most
dangerous during the human lifespan, with infection-related mortality being one of the …

Sulfated lactosyl archaeol archaeosomes synergize with poly (I: C) to enhance the immunogenicity and efficacy of a synthetic long peptide-based vaccine in a …

B Akache, G Agbayani, FC Stark, Y Jia, R Dudani… - Pharmaceutics, 2021 - mdpi.com
Cancer remains a leading cause of morbidity and mortality worldwide. While novel
treatments have improved survival outcomes for some patients, new treatment …

Recent and future advances in the chemoenzymatic synthesis of homogeneous glycans for bacterial glycoconjugate vaccine development

A Adegbite, PC McCarthy - Vaccines, 2021 - mdpi.com
Vaccines are important in preventing disease outbreaks and controlling the spread of
disease in a population. A variety of vaccines exist, including subunit, recombinant, and …