Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …

The intestinal reclamation of bile acids is crucial for the maintenance of their enterohepatic
circulation. The majority of bile acids are actively absorbed via specific transport proteins …

The liver is a central organ that performs a wide range of functions such as detoxification
and metabolic homeostasis. Since it is a metabolically active organ, liver is particularly …

Non-alcoholic steatohepatitis (NASH) represents a global health concern. It is characterised
by fatty liver, hepatocyte cell death and inflammation, which are associated with lipotoxicity …

Oxidative stress plays a major role in acute and chronic liver injury. In hepatocytes, oxidative
stress frequently triggers antioxidant response by activating nuclear erythroid 2‐related …

The Notch signaling pathway enables regulation and control of development, differentiation,
and homeostasis through cell-cell communication. Our investigation shows that Notch …

Bile acids has gradually become a new focus in various diseases, and ASBT as a
transporter responsible for the reabsorption of ileal bile acids, is a key hinge associated to …

We sought to identify factors that are predictive of liver transplantation or death in patients
with primary sclerosing cholangitis (PSC), and to develop and validate a contemporaneous …

A joint meeting of the European Association for the Study of the Liver (EASL) and the
American Association for the Study of Liver Diseases (AASLD) was held in London on …

Bile acids (BAs) are known to regulate BA synthesis and transport by the farnesoid X
receptor in the liver (FXR-SHP) and intestine (FXR-Fgf15). However, the relative importance …