Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates …
LE Tebay, H Robertson, ST Durant, SR Vitale… - Free Radical Biology …, 2015 - Elsevier
Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …
inducible expression of a battery of genes encoding key components of the glutathione …
[HTML][HTML] Intestinal absorption of bile acids in health and disease
AL Ticho, P Malhotra, PK Dudeja, RK Gill… - Comprehensive …, 2019 - ncbi.nlm.nih.gov
The intestinal reclamation of bile acids is crucial for the maintenance of their enterohepatic
circulation. The majority of bile acids are actively absorbed via specific transport proteins …
circulation. The majority of bile acids are actively absorbed via specific transport proteins …
Role of the Nrf2‐ARE pathway in liver diseases
SM Shin, JH Yang, SH Ki - Oxidative medicine and cellular …, 2013 - Wiley Online Library
The liver is a central organ that performs a wide range of functions such as detoxification
and metabolic homeostasis. Since it is a metabolically active organ, liver is particularly …
and metabolic homeostasis. Since it is a metabolically active organ, liver is particularly …
[HTML][HTML] Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2
B Bathish, H Robertson, JF Dillon… - Free Radical Biology …, 2022 - Elsevier
Non-alcoholic steatohepatitis (NASH) represents a global health concern. It is characterised
by fatty liver, hepatocyte cell death and inflammation, which are associated with lipotoxicity …
by fatty liver, hepatocyte cell death and inflammation, which are associated with lipotoxicity …
Naturally occurring Nrf2 activators: potential in treatment of liver injury
Oxidative stress plays a major role in acute and chronic liver injury. In hepatocytes, oxidative
stress frequently triggers antioxidant response by activating nuclear erythroid 2‐related …
stress frequently triggers antioxidant response by activating nuclear erythroid 2‐related …
Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling
N Wakabayashi, JJ Skoko… - … and cellular biology, 2014 - Taylor & Francis
The Notch signaling pathway enables regulation and control of development, differentiation,
and homeostasis through cell-cell communication. Our investigation shows that Notch …
and homeostasis through cell-cell communication. Our investigation shows that Notch …
[HTML][HTML] ASBT (SLC10A2): A promising target for treatment of diseases and drug discovery
N Yang, YQ Dong, GX Jia, SM Fan, SZ Li… - Biomedicine & …, 2020 - Elsevier
Bile acids has gradually become a new focus in various diseases, and ASBT as a
transporter responsible for the reabsorption of ileal bile acids, is a key hinge associated to …
transporter responsible for the reabsorption of ileal bile acids, is a key hinge associated to …
[PDF][PDF] Factors associated with outcomes of patients with primary sclerosing cholangitis and development and validation of a risk scoring system
EC Goode, AB Clark, GF Mells, B Srivastava… - …, 2019 - Wiley Online Library
We sought to identify factors that are predictive of liver transplantation or death in patients
with primary sclerosing cholangitis (PSC), and to develop and validate a contemporaneous …
with primary sclerosing cholangitis (PSC), and to develop and validate a contemporaneous …
[PDF][PDF] Alcohol‐related liver disease: areas of consensus, unmet needs and opportunities for further study
A joint meeting of the European Association for the Study of the Liver (EASL) and the
American Association for the Study of Liver Diseases (AASLD) was held in London on …
American Association for the Study of Liver Diseases (AASLD) was held in London on …
Individual bile acids have differential effects on bile acid signaling in mice
P Song, CE Rockwell, JY Cui, CD Klaassen - Toxicology and applied …, 2015 - Elsevier
Bile acids (BAs) are known to regulate BA synthesis and transport by the farnesoid X
receptor in the liver (FXR-SHP) and intestine (FXR-Fgf15). However, the relative importance …
receptor in the liver (FXR-SHP) and intestine (FXR-Fgf15). However, the relative importance …