The tragic health effects of nicotine addiction highlight the importance of investigating the
cellular mechanisms of this complex behavioral phenomenon. The chain of cause and effect …

Lorna W. Role* and Darwin K. Berg† Heinemann et al., 1990a; Sargent, 1993; Patrick et al.,*
Department of Cell Biology and Anatomy 1993). Eight are designated as α-type (α2–α9) and …

The behavioral and cognitive effects of nicotine suggest that nicotinic acetylcholine
receptors (nAChRs) participate in central nervous system (CNS) function. Although nAChR …

GIuRC, a subunit of high affinity kainate receptor channels in the mammalian CNS, carries a
glutamine (Q) or arginine (R) residue in a critical position (Q/R site) of the putative channel …

This review covers history underlying the discovery of the molecular mediators of nicotine's
effects in the brain and the diversity of the nicotinic acetylcholine receptor (nAChR) …

The α 7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …

Postsynaptic nAChRs in the peripheral nervous system are critical for neuromuscular and
autonomic neurotransmission. Pre-and peri-synaptic nAChRs in the brain modulate …

Many behavioral effects of nicotine result from activation of nigrostriatal and mesolimbic
dopaminergic systems. Nicotine regulates dopamine release not only by stimulation of …

Neuronal nicotinic acetylcholine receptors are oligomeric protein complexes whose
component subunits are each encoded by a family of homologous genes. The current …

Background Dysfunction of basocortical cholinergic projection neurons of the nucleus
basalis (NB) correlates with cognitive deficits in Alzheimer disease (AD). Nucleus basalis …